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Virulent Poxviruses Inhibit DNA Sensing by Preventing STING Activation

Cytosolic recognition of DNA has emerged as a critical cellular mechanism of host immune activation upon pathogen invasion. The central cytosolic DNA sensor cGAS activates STING, which is phosphorylated, dimerizes and translocates from the endoplasmic reticulum (ER) to a perinuclear region to mediat...

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Detalles Bibliográficos
Autores principales:	Georgana, Iliana, Sumner, Rebecca P., Towers, Greg J., Maluquer de Motes, Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Virus-Cell Interactions
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923072/ https://www.ncbi.nlm.nih.gov/pubmed/29491158 http://dx.doi.org/10.1128/JVI.02145-17

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