Heavy Metal Resistance Genes Are Associated with bla(NDM-1)- and bla(CTX-M-15)-Carrying Enterobacteriaceae

The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing bla(NDM-1) or bla(CTX-M-15) genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA gen...

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Detalles Bibliográficos
Autores principales: Yang, Qiu E., Agouri, Siham Rajab, Tyrrell, Jonathan Mark, Walsh, Timothy Rutland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923091/
https://www.ncbi.nlm.nih.gov/pubmed/29507071
http://dx.doi.org/10.1128/AAC.02642-17
Descripción
Sumario:The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing bla(NDM-1) or bla(CTX-M-15) genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes occurred with higher frequencies in bla(NDM-1)-positive (48.8% to 71.8%) and bla(CTX-M-15)-positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae, increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment.

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