Heavy Metal Resistance Genes Are Associated with bla(NDM-1)- and bla(CTX-M-15)-Carrying Enterobacteriaceae

The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing bla(NDM-1) or bla(CTX-M-15) genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA gen...

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Autores principales: Yang, Qiu E., Agouri, Siham Rajab, Tyrrell, Jonathan Mark, Walsh, Timothy Rutland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923091/
https://www.ncbi.nlm.nih.gov/pubmed/29507071
http://dx.doi.org/10.1128/AAC.02642-17
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author Yang, Qiu E.
Agouri, Siham Rajab
Tyrrell, Jonathan Mark
Walsh, Timothy Rutland
author_facet Yang, Qiu E.
Agouri, Siham Rajab
Tyrrell, Jonathan Mark
Walsh, Timothy Rutland
author_sort Yang, Qiu E.
collection PubMed
description The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing bla(NDM-1) or bla(CTX-M-15) genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes occurred with higher frequencies in bla(NDM-1)-positive (48.8% to 71.8%) and bla(CTX-M-15)-positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae, increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment.
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spelling pubmed-59230912018-05-11 Heavy Metal Resistance Genes Are Associated with bla(NDM-1)- and bla(CTX-M-15)-Carrying Enterobacteriaceae Yang, Qiu E. Agouri, Siham Rajab Tyrrell, Jonathan Mark Walsh, Timothy Rutland Antimicrob Agents Chemother Mechanisms of Resistance The occurrence of heavy metal resistance genes in multiresistant Enterobacteriaceae possessing bla(NDM-1) or bla(CTX-M-15) genes was examined by PCR and pulsed-field gel electrophoresis with S1 nuclease. Compared with clinical susceptible isolates (10.0% to 30.0%), the pcoA, merA, silC, and arsA genes occurred with higher frequencies in bla(NDM-1)-positive (48.8% to 71.8%) and bla(CTX-M-15)-positive (19.4% to 52.8%) isolates, and they were mostly located on plasmids. Given the high association of metal resistance genes with multidrug-resistant Enterobacteriaceae, increased vigilance needs to be taken with the use of heavy metals in hospitals and the environment. American Society for Microbiology 2018-04-26 /pmc/articles/PMC5923091/ /pubmed/29507071 http://dx.doi.org/10.1128/AAC.02642-17 Text en Copyright © 2018 Yang et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Mechanisms of Resistance
Yang, Qiu E.
Agouri, Siham Rajab
Tyrrell, Jonathan Mark
Walsh, Timothy Rutland
Heavy Metal Resistance Genes Are Associated with bla(NDM-1)- and bla(CTX-M-15)-Carrying Enterobacteriaceae
title Heavy Metal Resistance Genes Are Associated with bla(NDM-1)- and bla(CTX-M-15)-Carrying Enterobacteriaceae
title_full Heavy Metal Resistance Genes Are Associated with bla(NDM-1)- and bla(CTX-M-15)-Carrying Enterobacteriaceae
title_fullStr Heavy Metal Resistance Genes Are Associated with bla(NDM-1)- and bla(CTX-M-15)-Carrying Enterobacteriaceae
title_full_unstemmed Heavy Metal Resistance Genes Are Associated with bla(NDM-1)- and bla(CTX-M-15)-Carrying Enterobacteriaceae
title_short Heavy Metal Resistance Genes Are Associated with bla(NDM-1)- and bla(CTX-M-15)-Carrying Enterobacteriaceae
title_sort heavy metal resistance genes are associated with bla(ndm-1)- and bla(ctx-m-15)-carrying enterobacteriaceae
topic Mechanisms of Resistance
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923091/
https://www.ncbi.nlm.nih.gov/pubmed/29507071
http://dx.doi.org/10.1128/AAC.02642-17
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