Complex Interplay between Sphingolipid and Sterol Metabolism Revealed by Perturbations to the Leishmania Metabolome Caused by Miltefosine

With the World Health Organization reporting over 30,000 deaths and 200,000 to 400,000 new cases annually, visceral leishmaniasis is a serious disease affecting some of the world's poorest people. As drug resistance continues to rise, there is a huge unmet need to improve treatment. Miltefosine...

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Detalles Bibliográficos
Autores principales: Armitage, Emily G., Alqaisi, Amjed Q. I., Godzien, Joanna, Peña, Imanol, Mbekeani, Alison J., Alonso-Herranz, Vanesa, López-Gonzálvez, Ángeles, Martín, Julio, Gabarro, Raquel, Denny, Paul W., Barrett, Michael P., Barbas, Coral
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923112/
https://www.ncbi.nlm.nih.gov/pubmed/29463533
http://dx.doi.org/10.1128/AAC.02095-17

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