Cargando…

MEDI3902 Correlates of Protection against Severe Pseudomonas aeruginosa Pneumonia in a Rabbit Acute Pneumonia Model

Pseudomonas aeruginosa is among the most formidable antibiotic-resistant pathogens and is a leading cause of hospital-associated infections. With dwindling options for antibiotic-resistant infections, a new paradigm for treatment and disease resolution is required. MEDI3902, a bispecific antibody ta...

Descripción completa

Detalles Bibliográficos
Autores principales:	Le, Hoan N., Quetz, Josiane Silva, Tran, Vuvi G., Le, Vien T. M., Aguiar-Alves, Fábio, Pinheiro, Marcos G., Cheng, Lily, Yu, Li, Sellman, Bret R., Stover, Charles K., DiGiandomenico, Antonio, Diep, Binh An
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Clinical Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923159/ https://www.ncbi.nlm.nih.gov/pubmed/29483116 http://dx.doi.org/10.1128/AAC.02565-17

Ejemplares similares

Treatment Efficacy of MEDI3902 in Pseudomonas aeruginosa Bloodstream Infection and Acute Pneumonia Rabbit Models
por: Le, Hoan N., et al.
Publicado: (2019)

Antivirulence Bispecific Monoclonal Antibody-Mediated Protection against Pseudomonas aeruginosa Ventilator-Associated Pneumonia in a Rabbit Model
por: Aguiar-Alves, Fábio, et al.
Publicado: (2022)

Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity In Vitro and Staphylococcus aureus Fitness in Infection Models
por: Tkaczyk, C., et al.
Publicado: (2018)

Safety, efficacy, and pharmacokinetics of gremubamab (MEDI3902), an anti-Pseudomonas aeruginosa bispecific human monoclonal antibody, in P. aeruginosa-colonised, mechanically ventilated intensive care unit patients: a randomised controlled trial
por: Chastre, Jean, et al.
Publicado: (2022)

697. Pseudomonas aeruginosa PcrV and Psl, the Molecular Targets of Bispecific Monoclonal Antibody MEDI3902, Are Conserved Among Diverse Hospital Isolates Collected From an International Surveillance Study
por: Tabor, David E
Publicado: (2018)

Treatment and Prophylaxis of Pneumocystis carinii Pneumonia in AIDS Patients
por: Smith, Don, et al.
Publicado: (2012)

Safety, Tolerability, and Pharmacokinetics of MEDI4893, an Investigational, Extended-Half-Life, Anti-Staphylococcus aureus Alpha-Toxin Human Monoclonal Antibody, in Healthy Adults
por: Yu, Xiang-Qing, et al.
Publicado: (2016)

713. Preventive Administration of MEDI6389, a Combination of Monoclonal Antibodies (mAbs) Targeting Alpha-Toxin (AT), Panton-Valentine Leukocidin (PVL), Leukocidin ED (LukED), Gamma-Hemolysin and Clumping Factor A (ClfA), in a Rabbit Model of USA300 MRSA Prosthetic Joint Infection (PJI)
por: Yanjie, Mao, et al.
Publicado: (2019)

Evaluation of Gallium Citrate Formulations against a Multidrug-Resistant Strain of Klebsiella pneumoniae in a Murine Wound Model of Infection
por: Thompson, Mitchell G., et al.
Publicado: (2015)

Differential Expression and Roles of Staphylococcus aureus Virulence Determinants during Colonization and Disease
por: Jenkins, Amy, et al.
Publicado: (2015)

Antibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function
por: Jones-Nelson, Omari, et al.
Publicado: (2020)

Efficacy of Cefiderocol in Experimental Stenotrophomonas maltophilia Pneumonia in Persistently Neutropenic Rabbits
por: Petraitis, Vidmantas, et al.
Publicado: (2022)

1.55 Å resolution X-ray crystal structure of Rv3902c from Mycobacterium tuberculosis
por: Reddy, Bharat G., et al.
Publicado: (2014)

Efficacy of Rezafungin in Prophylactic Mouse Models of Invasive Candidiasis, Aspergillosis, and Pneumocystis Pneumonia
por: Miesel, Lynn, et al.
Publicado: (2021)

Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach
por: Tkaczyk, C., et al.
Publicado: (2017)

Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin
por: Rodgers, Aoife M., et al.
Publicado: (2019)

Prophylaxis for Pneumocystis jirovecii pneumonia in patients with inflammatory bowel disease: A systematic review
por: Sierra, Caroline M., et al.
Publicado: (2022)

APX001 and Other Gwt1 Inhibitor Prodrugs Are Effective in Experimental Coccidioides immitis Pneumonia
por: Viriyakosol, Suganya, et al.
Publicado: (2019)

635. Efficacy, Pharmacokinetics (PK), and Safety Profile of MEDI3902, an Anti-Pseudomonas aeruginosa Bispecific Human Monoclonal Antibody in Mechanically Ventilated Intensive Care Unit Patients; Results of the Phase 2 EVADE Study Conducted by the Public-Private COMBACTE-MAGNET Consortium in the Innovative Medicines Initiative (IMI) Program
por: Chastre, Jean, et al.
Publicado: (2020)

An engineered bispecific DNA-encoded IgG antibody protects against Pseudomonas aeruginosa in a pneumonia challenge model
por: Patel, Ami, et al.
Publicado: (2017)

Exposure–Efficacy Analyses Support Optimal Dosing Regimens of Ceftolozane/Tazobactam in Participants with Hospital-Acquired/Ventilator-Associated Bacterial Pneumonia in ASPECT-NP
por: Gao, Wei, et al.
Publicado: (2022)

Medi-wiki worries?
por: Mason, Fred
Publicado: (2009)

MediNet: transfer learning approach with MediNet medical visual database
por: Reis, Hatice Catal, et al.
Publicado: (2023)

In vitro efficacy of humanized regimen of flomoxef against extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae
por: Yamashiro, Hidenori, et al.
Publicado: (2023)

First-in-Human, Phase 1 Dose-Escalation Study of Biparatopic Anti-HER2 Antibody–Drug Conjugate MEDI4276 in Patients with HER2-positive Advanced Breast or Gastric Cancer
por: Pegram, Mark D., et al.
Publicado: (2021)

Multifunctional Monoclonal Antibody Targeting Pseudomonas aeruginosa Keratitis in Mice
por: Hebert, Wesley, et al.
Publicado: (2020)

Monoclonal antibodies neutralizing alpha-hemolysin, bicomponent leukocidins, and clumping factor A protected against Staphylococcus aureus-induced acute circulatory failure in a mechanically ventilated rabbit model of hyperdynamic septic shock
por: Nguyen, Nhu T. Q., et al.
Publicado: (2023)

Dose‐Response Analysis of the Effect of Carbidopa‐Levodopa Extended‐Release Capsules (IPX066) in Levodopa‐Naive Patients With Parkinson Disease
por: Mao, Zhongping Lily, et al.
Publicado: (2016)

2202. Validation of a Rabbit Model of Pseudomonas aeruginosa Acute Pneumonia
por: Gras, Emmanuelle, et al.
Publicado: (2019)

Pharmacokinetics and Safety of XAV-19, a Swine Glyco-humanized Polyclonal Anti-SARS-CoV-2 Antibody, for COVID-19-Related Moderate Pneumonia: a Randomized, Double-Blind, Placebo-Controlled, Phase IIa Study
por: Gaborit, Benjamin, et al.
Publicado: (2021)

Exploring Virulence Factors and Alternative Therapies against Staphylococcus aureus Pneumonia
por: Vlaeminck, Jelle, et al.
Publicado: (2020)

Staphylococcus aureus Alpha-Toxin Is Conserved among Diverse Hospital Respiratory Isolates Collected from a Global Surveillance Study and Is Neutralized by Monoclonal Antibody MEDI4893
por: Tabor, David E., et al.
Publicado: (2016)

Cystatins 9 and C as a Novel Immunotherapy Treatment That Protects against Multidrug-Resistant New Delhi Metallo-Beta-Lactamase-1-Producing Klebsiella pneumoniae
por: Holloway, Alex J., et al.
Publicado: (2018)

Combination of Cystatins 9 and C Modulates Serum Biomarkers Associated with Inflammation and Provides Prophylactic as Well as Long-Term Protection against Multidrug-Resistant Klebsiella pneumoniae
por: Holloway, Alex J., et al.
Publicado: (2019)

Multicomponent Pseudomonas aeruginosa Vaccines Eliciting Th17 Cells and Functional Antibody Responses Confer Enhanced Protection against Experimental Acute Pneumonia in Mice
por: Shaikh, Mohammad Omar Faruk, et al.
Publicado: (2022)

Influence of Prednisone on Inflammatory Biomarkers in Community‐Acquired Pneumonia: Secondary Analysis of a Randomized Trial
por: Raess, Natalie, et al.
Publicado: (2021)

Efficacy of Delafloxacin versus Moxifloxacin against Bacterial Respiratory Pathogens in Adults with Community-Acquired Bacterial Pneumonia (CABP): Microbiology Results from the Delafloxacin Phase 3 CABP Trial
por: McCurdy, Sandra, et al.
Publicado: (2020)

Art, ciéncia i medi natural.
Publicado: (1994)

Medie and Info-pubmed: 2010 update
por: Ohta, Tomoko, et al.
Publicado: (2010)

Anti-Psl Targeting of Pseudomonas aeruginosa Biofilms for Neutrophil-Mediated Disruption
por: Ray, Valerie A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_sj9gpn9dncfm8kj09noli5jtph