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Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System
The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923160/ https://www.ncbi.nlm.nih.gov/pubmed/29463538 http://dx.doi.org/10.1128/AAC.00250-18 |
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| author | Fernández-García, Laura Fernandez-Cuenca, Felipe Blasco, Lucía López-Rojas, Rafael Ambroa, Anton Lopez, María Pascual, Álvaro Bou, Germán Tomás, María |
| author_facet | Fernández-García, Laura Fernandez-Cuenca, Felipe Blasco, Lucía López-Rojas, Rafael Ambroa, Anton Lopez, María Pascual, Álvaro Bou, Germán Tomás, María |
| author_sort | Fernández-García, Laura |
| collection | PubMed |
| description | The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine. |
| format | Online Article Text |
| id | pubmed-5923160 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | American Society for Microbiology |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59231602018-05-11 Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System Fernández-García, Laura Fernandez-Cuenca, Felipe Blasco, Lucía López-Rojas, Rafael Ambroa, Anton Lopez, María Pascual, Álvaro Bou, Germán Tomás, María Antimicrob Agents Chemother Mechanisms of Action: Physiological Effects The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine. American Society for Microbiology 2018-04-26 /pmc/articles/PMC5923160/ /pubmed/29463538 http://dx.doi.org/10.1128/AAC.00250-18 Text en Copyright © 2018 Fernández-García et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Mechanisms of Action: Physiological Effects Fernández-García, Laura Fernandez-Cuenca, Felipe Blasco, Lucía López-Rojas, Rafael Ambroa, Anton Lopez, María Pascual, Álvaro Bou, Germán Tomás, María Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System |
| title | Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System |
| title_full | Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System |
| title_fullStr | Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System |
| title_full_unstemmed | Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System |
| title_short | Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System |
| title_sort | relationship between tolerance and persistence mechanisms in acinetobacter baumannii strains with abkab toxin-antitoxin system |
| topic | Mechanisms of Action: Physiological Effects |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923160/ https://www.ncbi.nlm.nih.gov/pubmed/29463538 http://dx.doi.org/10.1128/AAC.00250-18 |
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