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A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing

Subsets of endogenous retroviruses (ERVs) are derepressed in mouse embryonic stem cells (mESCs) deficient for Setdb1, which catalyzes histone H3 lysine 9 trimethylation (H3K9me3). Most of those ERVs, including IAPs, remain silent if Setdb1 is deleted in differentiated embryonic cells; however they a...

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Detalles Bibliográficos
Autores principales:	Kato, Masaki, Takemoto, Keiko, Shinkai, Yoichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923290/ https://www.ncbi.nlm.nih.gov/pubmed/29703894 http://dx.doi.org/10.1038/s41467-018-04132-9

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