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Dose-Response Modelling of Paralytic Shellfish Poisoning (PSP) in Humans

Paralytic shellfish poisoning (PSP) is caused by a group of marine toxins with saxitoxin (STX) as the reference compound. Symptoms in humans after consumption of contaminated shellfish vary from slight neurological and gastrointestinal effects to fatal respiratory paralysis. A systematic review was...

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Autores principales: Arnich, Nathalie, Thébault, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923307/
https://www.ncbi.nlm.nih.gov/pubmed/29597338
http://dx.doi.org/10.3390/toxins10040141
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author Arnich, Nathalie
Thébault, Anne
author_facet Arnich, Nathalie
Thébault, Anne
author_sort Arnich, Nathalie
collection PubMed
description Paralytic shellfish poisoning (PSP) is caused by a group of marine toxins with saxitoxin (STX) as the reference compound. Symptoms in humans after consumption of contaminated shellfish vary from slight neurological and gastrointestinal effects to fatal respiratory paralysis. A systematic review was conducted to identify reported cases of human poisoning associated with the ingestion of shellfish contaminated with paralytic shellfish toxins (PSTs). Raw data were collected from 143 exposed individuals (113 with symptoms, 30 without symptoms) from 13 studies. Exposure estimates were based on mouse bioassays except in one study. A significant relationship between exposure to PSTs and severity of symptoms was established by ordinal modelling. The critical minimal dose with a probability higher than 10% of showing symptoms is 0.37 µg STX eq./kg b.w. This means that 10% of the individuals exposed to this dose would have symptoms (without considering the severity of the symptoms). This dose is four-fold lower than the lowest-observed-adverse-effect-level (LOAEL) established by the European Food Safety Authority (EFSA, 2009) in the region of 1.5 μg STX eq./kg b.w. This work provides critical doses that could be used as point of departure to update the acute reference dose for STX. This is the first time a dose-symptoms model could be built for marine toxins using epidemiological data.
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spelling pubmed-59233072018-05-03 Dose-Response Modelling of Paralytic Shellfish Poisoning (PSP) in Humans Arnich, Nathalie Thébault, Anne Toxins (Basel) Article Paralytic shellfish poisoning (PSP) is caused by a group of marine toxins with saxitoxin (STX) as the reference compound. Symptoms in humans after consumption of contaminated shellfish vary from slight neurological and gastrointestinal effects to fatal respiratory paralysis. A systematic review was conducted to identify reported cases of human poisoning associated with the ingestion of shellfish contaminated with paralytic shellfish toxins (PSTs). Raw data were collected from 143 exposed individuals (113 with symptoms, 30 without symptoms) from 13 studies. Exposure estimates were based on mouse bioassays except in one study. A significant relationship between exposure to PSTs and severity of symptoms was established by ordinal modelling. The critical minimal dose with a probability higher than 10% of showing symptoms is 0.37 µg STX eq./kg b.w. This means that 10% of the individuals exposed to this dose would have symptoms (without considering the severity of the symptoms). This dose is four-fold lower than the lowest-observed-adverse-effect-level (LOAEL) established by the European Food Safety Authority (EFSA, 2009) in the region of 1.5 μg STX eq./kg b.w. This work provides critical doses that could be used as point of departure to update the acute reference dose for STX. This is the first time a dose-symptoms model could be built for marine toxins using epidemiological data. MDPI 2018-03-28 /pmc/articles/PMC5923307/ /pubmed/29597338 http://dx.doi.org/10.3390/toxins10040141 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Arnich, Nathalie
Thébault, Anne
Dose-Response Modelling of Paralytic Shellfish Poisoning (PSP) in Humans
title Dose-Response Modelling of Paralytic Shellfish Poisoning (PSP) in Humans
title_full Dose-Response Modelling of Paralytic Shellfish Poisoning (PSP) in Humans
title_fullStr Dose-Response Modelling of Paralytic Shellfish Poisoning (PSP) in Humans
title_full_unstemmed Dose-Response Modelling of Paralytic Shellfish Poisoning (PSP) in Humans
title_short Dose-Response Modelling of Paralytic Shellfish Poisoning (PSP) in Humans
title_sort dose-response modelling of paralytic shellfish poisoning (psp) in humans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923307/
https://www.ncbi.nlm.nih.gov/pubmed/29597338
http://dx.doi.org/10.3390/toxins10040141
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