Cargando…

New Insights from Elucidating the Role of LMP1 in Nasopharyngeal Carcinoma

Latent membrane protein 1 (LMP1) is an Epstein-Barr virus (EBV) oncogenic protein that has no intrinsic enzymatic activity or sequence homology to cellular or viral proteins. The oncogenic potential of LMP1 has been ascribed to pleiotropic signaling properties initiated through protein-protein inter...

Descripción completa

Detalles Bibliográficos
Autores principales: Shair, Kathy H. Y., Reddy, Akhil, Cooper, Vaughn S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923341/
https://www.ncbi.nlm.nih.gov/pubmed/29561768
http://dx.doi.org/10.3390/cancers10040086
_version_ 1783318319226421248
author Shair, Kathy H. Y.
Reddy, Akhil
Cooper, Vaughn S.
author_facet Shair, Kathy H. Y.
Reddy, Akhil
Cooper, Vaughn S.
author_sort Shair, Kathy H. Y.
collection PubMed
description Latent membrane protein 1 (LMP1) is an Epstein-Barr virus (EBV) oncogenic protein that has no intrinsic enzymatic activity or sequence homology to cellular or viral proteins. The oncogenic potential of LMP1 has been ascribed to pleiotropic signaling properties initiated through protein-protein interactions in cytosolic membrane compartments, but the effects of LMP1 extend to nuclear and extracellular processes. Although LMP1 is one of the latent genes required for EBV-immortalization of B cells, the biology of LMP1 in the pathogenesis of the epithelial cancer nasopharyngeal carcinoma (NPC) is more complex. NPC is prevalent in specific regions of the world with high incidence in southeast China. The epidemiology and time interval from seroconversion to NPC onset in adults would suggest the involvement of multiple risk factors that complement the establishment of a latent and persistent EBV infection. The contribution of LMP1 to EBV pathogenesis in polarized epithelia has only recently begun to be elucidated. Furthermore, the LMP1 gene has emerged as one of the most divergent sequences in the EBV genome. This review will discuss the significance of recent advances in NPC research from elucidating LMP1 function in epithelial cells and lessons that could be learned from mining LMP1 sequence diversity.
format Online
Article
Text
id pubmed-5923341
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-59233412018-05-03 New Insights from Elucidating the Role of LMP1 in Nasopharyngeal Carcinoma Shair, Kathy H. Y. Reddy, Akhil Cooper, Vaughn S. Cancers (Basel) Review Latent membrane protein 1 (LMP1) is an Epstein-Barr virus (EBV) oncogenic protein that has no intrinsic enzymatic activity or sequence homology to cellular or viral proteins. The oncogenic potential of LMP1 has been ascribed to pleiotropic signaling properties initiated through protein-protein interactions in cytosolic membrane compartments, but the effects of LMP1 extend to nuclear and extracellular processes. Although LMP1 is one of the latent genes required for EBV-immortalization of B cells, the biology of LMP1 in the pathogenesis of the epithelial cancer nasopharyngeal carcinoma (NPC) is more complex. NPC is prevalent in specific regions of the world with high incidence in southeast China. The epidemiology and time interval from seroconversion to NPC onset in adults would suggest the involvement of multiple risk factors that complement the establishment of a latent and persistent EBV infection. The contribution of LMP1 to EBV pathogenesis in polarized epithelia has only recently begun to be elucidated. Furthermore, the LMP1 gene has emerged as one of the most divergent sequences in the EBV genome. This review will discuss the significance of recent advances in NPC research from elucidating LMP1 function in epithelial cells and lessons that could be learned from mining LMP1 sequence diversity. MDPI 2018-03-21 /pmc/articles/PMC5923341/ /pubmed/29561768 http://dx.doi.org/10.3390/cancers10040086 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shair, Kathy H. Y.
Reddy, Akhil
Cooper, Vaughn S.
New Insights from Elucidating the Role of LMP1 in Nasopharyngeal Carcinoma
title New Insights from Elucidating the Role of LMP1 in Nasopharyngeal Carcinoma
title_full New Insights from Elucidating the Role of LMP1 in Nasopharyngeal Carcinoma
title_fullStr New Insights from Elucidating the Role of LMP1 in Nasopharyngeal Carcinoma
title_full_unstemmed New Insights from Elucidating the Role of LMP1 in Nasopharyngeal Carcinoma
title_short New Insights from Elucidating the Role of LMP1 in Nasopharyngeal Carcinoma
title_sort new insights from elucidating the role of lmp1 in nasopharyngeal carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923341/
https://www.ncbi.nlm.nih.gov/pubmed/29561768
http://dx.doi.org/10.3390/cancers10040086
work_keys_str_mv AT shairkathyhy newinsightsfromelucidatingtheroleoflmp1innasopharyngealcarcinoma
AT reddyakhil newinsightsfromelucidatingtheroleoflmp1innasopharyngealcarcinoma
AT coopervaughns newinsightsfromelucidatingtheroleoflmp1innasopharyngealcarcinoma