Ubiquitin-Dependent Regulation of the Mammalian Hippo Pathway: Therapeutic Implications for Cancer

The Hippo pathway serves as a key barrier for oncogenic transformation. It acts by limiting the activity of the proto-oncogenes YAP and TAZ. Reduced Hippo signaling and elevated YAP/TAZ activities are frequently observed in various types of tumors. Emerging evidence suggests that the ubiquitin syste...

Descripción completa

Detalles Bibliográficos
Autores principales: Nguyen, Thanh Hung, Kugler, Jan-Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923376/
https://www.ncbi.nlm.nih.gov/pubmed/29673168
http://dx.doi.org/10.3390/cancers10040121

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923376/
https://www.ncbi.nlm.nih.gov/pubmed/29673168
http://dx.doi.org/10.3390/cancers10040121

Ejemplares similares