Cargando…

Ubiquitin-Dependent Regulation of the Mammalian Hippo Pathway: Therapeutic Implications for Cancer

The Hippo pathway serves as a key barrier for oncogenic transformation. It acts by limiting the activity of the proto-oncogenes YAP and TAZ. Reduced Hippo signaling and elevated YAP/TAZ activities are frequently observed in various types of tumors. Emerging evidence suggests that the ubiquitin syste...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nguyen, Thanh Hung, Kugler, Jan-Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923376/ https://www.ncbi.nlm.nih.gov/pubmed/29673168 http://dx.doi.org/10.3390/cancers10040121

Ejemplares similares

RhoBTB Proteins Regulate the Hippo Pathway by Antagonizing Ubiquitination of LKB1
por: Nguyen, Thanh Hung, et al.
Publicado: (2020)

DUB3 Deubiquitylating Enzymes Regulate Hippo Pathway Activity by Regulating the Stability of ITCH, LATS and AMOT Proteins
por: Nguyen, Hung Thanh, et al.
Publicado: (2017)

USP21 regulates Hippo pathway activity by mediating MARK protein turnover
por: Nguyen, Hung Thanh, et al.
Publicado: (2017)

Regulation of the Hippo signaling pathway by ubiquitin modification
por: Kim, Youngeun, et al.
Publicado: (2018)

Regulation of Tissue Growth by the Mammalian Hippo Signaling Pathway
por: Watt, Kevin I., et al.
Publicado: (2017)

Regulation of ferroptosis in cancer cells by YAP/TAZ and Hippo pathways: The therapeutic implications
por: Sun, Tianai, et al.
Publicado: (2020)

Hippo Pathway in Mammalian Adaptive Immune System
por: Yamauchi, Takayoshi, et al.
Publicado: (2019)

Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets
por: Porazinski, Sean, et al.
Publicado: (2018)

Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover
por: Hong, Xin, et al.
Publicado: (2014)

The Hippo Pathway Blocks Mammalian Retinal Müller Glial Cell Reprogramming
por: Rueda, Elda M., et al.
Publicado: (2019)

MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway
por: Couzens, Amber L., et al.
Publicado: (2017)

Upstream regulators of the Hippo pathway
por: Yu, Fa-Xing, et al.
Publicado: (2012)

Mechanisms of Hippo pathway regulation
por: Meng, Zhipeng, et al.
Publicado: (2016)

Clinical implications of the Hippo-YAP pathway in multiple cancer contexts
por: Kim, Han-Byul, et al.
Publicado: (2018)

Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover
por: Thanh Nguyen, Hung, et al.
Publicado: (2016)

The Hippo pathway in endometrial cancer: a potential therapeutic target?
por: Shen, Xinyun, et al.
Publicado: (2023)

Regulation of Hippo signaling and triple negative breast cancer progression by an ubiquitin ligase RNF187
por: Wang, Zhonghao, et al.
Publicado: (2020)

Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration
por: Lu, Li, et al.
Publicado: (2018)

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
por: Cunningham, Richard, et al.
Publicado: (2022)

Willin, an Upstream Component of the Hippo Signaling Pathway, Orchestrates Mammalian Peripheral Nerve Fibroblasts
por: Moleirinho, Susana, et al.
Publicado: (2013)

Hippo Pathway in Cancer, towards the Realization of Hippo-Targeted Therapy
por: Hata, Yutaka
Publicado: (2018)

Diversity in function and regulation of the Hippo pathway
por: Zhou, Dawang
Publicado: (2013)

Regulation of the Hippo signaling pathway by deubiquitinating enzymes in cancer
por: Mussell, Ashley, et al.
Publicado: (2019)

The hippo signaling pathway: implications for heart regeneration and disease
por: Del Re, Dominic P
Publicado: (2014)

The Hippo Pathway: Immunity and Cancer
por: Taha, Zaid, et al.
Publicado: (2018)

The Hippo Pathway in Prostate Cancer
por: Salem, Omar, et al.
Publicado: (2019)

New Therapeutic Approach for Targeting Hippo Signalling Pathway
por: Dominguez-Berrocal, Leticia, et al.
Publicado: (2019)

The Hippo signaling pathway in gastric cancer: Targeting Hippo for GC treatment
por: Cao, Zhifa, et al.
Publicado: (2023)

Reciprocal Regulation of Hippo and WBP2 Signalling—Implications in Cancer Therapy
por: Lim, Yvonne Xinyi, et al.
Publicado: (2021)

RHPCG: a database of the Regulation of the Hippo Pathway in Cancer Genome
por: Wang, Chengyu, et al.
Publicado: (2019)

Mechanical strain regulates the Hippo pathway in Drosophila
por: Fletcher, Georgina C., et al.
Publicado: (2018)

Histone Acetylation-Mediated Regulation of the Hippo Pathway
por: Basu, Dipanjan, et al.
Publicado: (2013)

The Spectrin cytoskeleton regulates the Hippo signalling pathway
por: Fletcher, Georgina C, et al.
Publicado: (2015)

Hippo Pathway in Regulating Drug Resistance of Glioblastoma
por: Casati, Giacomo, et al.
Publicado: (2021)

The Regulation of the Hippo Pathway by Intercellular Junction Proteins
por: Ahmad, Usama Sharif, et al.
Publicado: (2022)

Emerging role of Hippo pathway in the regulation of hematopoiesis
por: Kim, Inyoung, et al.
Publicado: (2023)

Erratum to: The hippo signaling pathway: implications for heart regeneration and disease
por: Del Re, Dominic P
Publicado: (2015)

The Hippo signalling pathway and its implications in human health and diseases
por: Fu, Minyang, et al.
Publicado: (2022)

CRABP2 regulates invasion and metastasis of breast cancer through hippo pathway dependent on ER status
por: Feng, Xuefei, et al.
Publicado: (2019)

Regulation and functions of mammalian LATS/NDR kinases: looking beyond canonical Hippo signalling
por: Hergovich, Alexander
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_u6r7hpbc2vpftfam3p7vprsqjh