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Ubiquitin-Dependent Regulation of the Mammalian Hippo Pathway: Therapeutic Implications for Cancer

The Hippo pathway serves as a key barrier for oncogenic transformation. It acts by limiting the activity of the proto-oncogenes YAP and TAZ. Reduced Hippo signaling and elevated YAP/TAZ activities are frequently observed in various types of tumors. Emerging evidence suggests that the ubiquitin syste...

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Detalles Bibliográficos
Autores principales:	Nguyen, Thanh Hung, Kugler, Jan-Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923376/ https://www.ncbi.nlm.nih.gov/pubmed/29673168 http://dx.doi.org/10.3390/cancers10040121

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