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Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo
Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide (1), (E,E,E)-6,10,14-trimethyl-3-methylene-cis-3α,4,5,8,9,12,13,15α-octahydrocyclo tetradeca[β]furan-2(3H)-one...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923386/ https://www.ncbi.nlm.nih.gov/pubmed/29561805 http://dx.doi.org/10.3390/md16040099 |
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author | Kamada, Takashi Kang, Min-Cheol Phan, Chin-Soon Zanil, Intan Irna Jeon, You-Jin Vairappan, Charles S. |
author_facet | Kamada, Takashi Kang, Min-Cheol Phan, Chin-Soon Zanil, Intan Irna Jeon, You-Jin Vairappan, Charles S. |
author_sort | Kamada, Takashi |
collection | PubMed |
description | Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide (1), (E,E,E)-6,10,14-trimethyl-3-methylene-cis-3α,4,5,8,9,12,13,15α-octahydrocyclo tetradeca[β]furan-2(3H)-one (3), and denticulatolide (4), were isolated from the Bornean soft coral Sinularia sp. Compounds 2 and 4 showed potential anti-inflammatory activities against lipopolysaccharide-stimulated RAW 264.7 with IC(50) values less than 6.25 µg/mL and anticancer activity against HL60 cell lines. The compounds’ mechanisms of action were investigated via the Western blot evaluation of their protein markers. These activities could be attributed to the presence of tertiary methyl at C-8 and the compounds’ 3D configurations. |
format | Online Article Text |
id | pubmed-5923386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59233862018-05-03 Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo Kamada, Takashi Kang, Min-Cheol Phan, Chin-Soon Zanil, Intan Irna Jeon, You-Jin Vairappan, Charles S. Mar Drugs Article Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide (1), (E,E,E)-6,10,14-trimethyl-3-methylene-cis-3α,4,5,8,9,12,13,15α-octahydrocyclo tetradeca[β]furan-2(3H)-one (3), and denticulatolide (4), were isolated from the Bornean soft coral Sinularia sp. Compounds 2 and 4 showed potential anti-inflammatory activities against lipopolysaccharide-stimulated RAW 264.7 with IC(50) values less than 6.25 µg/mL and anticancer activity against HL60 cell lines. The compounds’ mechanisms of action were investigated via the Western blot evaluation of their protein markers. These activities could be attributed to the presence of tertiary methyl at C-8 and the compounds’ 3D configurations. MDPI 2018-03-21 /pmc/articles/PMC5923386/ /pubmed/29561805 http://dx.doi.org/10.3390/md16040099 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kamada, Takashi Kang, Min-Cheol Phan, Chin-Soon Zanil, Intan Irna Jeon, You-Jin Vairappan, Charles S. Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo |
title | Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo |
title_full | Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo |
title_fullStr | Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo |
title_full_unstemmed | Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo |
title_short | Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo |
title_sort | bioactive cembranoids from the soft coral genus sinularia sp. in borneo |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923386/ https://www.ncbi.nlm.nih.gov/pubmed/29561805 http://dx.doi.org/10.3390/md16040099 |
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