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Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo

Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide (1), (E,E,E)-6,10,14-trimethyl-3-methylene-cis-3α,4,5,8,9,12,13,15α-octahydrocyclo tetradeca[β]furan-2(3H)-one...

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Detalles Bibliográficos
Autores principales: Kamada, Takashi, Kang, Min-Cheol, Phan, Chin-Soon, Zanil, Intan Irna, Jeon, You-Jin, Vairappan, Charles S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923386/
https://www.ncbi.nlm.nih.gov/pubmed/29561805
http://dx.doi.org/10.3390/md16040099
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author Kamada, Takashi
Kang, Min-Cheol
Phan, Chin-Soon
Zanil, Intan Irna
Jeon, You-Jin
Vairappan, Charles S.
author_facet Kamada, Takashi
Kang, Min-Cheol
Phan, Chin-Soon
Zanil, Intan Irna
Jeon, You-Jin
Vairappan, Charles S.
author_sort Kamada, Takashi
collection PubMed
description Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide (1), (E,E,E)-6,10,14-trimethyl-3-methylene-cis-3α,4,5,8,9,12,13,15α-octahydrocyclo tetradeca[β]furan-2(3H)-one (3), and denticulatolide (4), were isolated from the Bornean soft coral Sinularia sp. Compounds 2 and 4 showed potential anti-inflammatory activities against lipopolysaccharide-stimulated RAW 264.7 with IC(50) values less than 6.25 µg/mL and anticancer activity against HL60 cell lines. The compounds’ mechanisms of action were investigated via the Western blot evaluation of their protein markers. These activities could be attributed to the presence of tertiary methyl at C-8 and the compounds’ 3D configurations.
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spelling pubmed-59233862018-05-03 Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo Kamada, Takashi Kang, Min-Cheol Phan, Chin-Soon Zanil, Intan Irna Jeon, You-Jin Vairappan, Charles S. Mar Drugs Article Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide (1), (E,E,E)-6,10,14-trimethyl-3-methylene-cis-3α,4,5,8,9,12,13,15α-octahydrocyclo tetradeca[β]furan-2(3H)-one (3), and denticulatolide (4), were isolated from the Bornean soft coral Sinularia sp. Compounds 2 and 4 showed potential anti-inflammatory activities against lipopolysaccharide-stimulated RAW 264.7 with IC(50) values less than 6.25 µg/mL and anticancer activity against HL60 cell lines. The compounds’ mechanisms of action were investigated via the Western blot evaluation of their protein markers. These activities could be attributed to the presence of tertiary methyl at C-8 and the compounds’ 3D configurations. MDPI 2018-03-21 /pmc/articles/PMC5923386/ /pubmed/29561805 http://dx.doi.org/10.3390/md16040099 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kamada, Takashi
Kang, Min-Cheol
Phan, Chin-Soon
Zanil, Intan Irna
Jeon, You-Jin
Vairappan, Charles S.
Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo
title Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo
title_full Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo
title_fullStr Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo
title_full_unstemmed Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo
title_short Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo
title_sort bioactive cembranoids from the soft coral genus sinularia sp. in borneo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923386/
https://www.ncbi.nlm.nih.gov/pubmed/29561805
http://dx.doi.org/10.3390/md16040099
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