Cargando…
Unique Collagen Fibers for Biomedical Applications
The challenge to develop grafts for tissue regeneration lies in the need to obtain a scaffold that will promote cell growth in order to form new tissue at a trauma-damaged site. Scaffolds also need to provide compatible mechanical properties that will support the new tissue and facilitate the desire...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923389/ https://www.ncbi.nlm.nih.gov/pubmed/29570651 http://dx.doi.org/10.3390/md16040102 |
_version_ | 1783318331042824192 |
---|---|
author | Benayahu, Dafna Sharabi, Mirit Pomeraniec, Leslie Awad, Lama Haj-Ali, Rami Benayahu, Yehuda |
author_facet | Benayahu, Dafna Sharabi, Mirit Pomeraniec, Leslie Awad, Lama Haj-Ali, Rami Benayahu, Yehuda |
author_sort | Benayahu, Dafna |
collection | PubMed |
description | The challenge to develop grafts for tissue regeneration lies in the need to obtain a scaffold that will promote cell growth in order to form new tissue at a trauma-damaged site. Scaffolds also need to provide compatible mechanical properties that will support the new tissue and facilitate the desired physiological activity. Here, we used natural materials to develop a bio-composite made of unique collagen embedded in an alginate hydrogel material. The collagen fibers used to create the building blocks exhibited a unique hyper-elastic behavior similar to that of natural human tissue. The prominent mechanical properties, along with the support of cell adhesion affects cell shape and supports their proliferation, consequently facilitating the formation of a new tissue-like structure. The current study elaborates on these unique collagen fibers, focusing on their structure and biocompatibility, in an in vitro model. The findings suggest it as a highly appropriate material for biomedical applications. The promising in vitro results indicate that the distinctive collagen fibers could serve as a scaffold that can be adapted for tissue regeneration, in support of healing processes, along with maintaining tissue mechanical properties for the new regenerate tissue formation. |
format | Online Article Text |
id | pubmed-5923389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59233892018-05-03 Unique Collagen Fibers for Biomedical Applications Benayahu, Dafna Sharabi, Mirit Pomeraniec, Leslie Awad, Lama Haj-Ali, Rami Benayahu, Yehuda Mar Drugs Article The challenge to develop grafts for tissue regeneration lies in the need to obtain a scaffold that will promote cell growth in order to form new tissue at a trauma-damaged site. Scaffolds also need to provide compatible mechanical properties that will support the new tissue and facilitate the desired physiological activity. Here, we used natural materials to develop a bio-composite made of unique collagen embedded in an alginate hydrogel material. The collagen fibers used to create the building blocks exhibited a unique hyper-elastic behavior similar to that of natural human tissue. The prominent mechanical properties, along with the support of cell adhesion affects cell shape and supports their proliferation, consequently facilitating the formation of a new tissue-like structure. The current study elaborates on these unique collagen fibers, focusing on their structure and biocompatibility, in an in vitro model. The findings suggest it as a highly appropriate material for biomedical applications. The promising in vitro results indicate that the distinctive collagen fibers could serve as a scaffold that can be adapted for tissue regeneration, in support of healing processes, along with maintaining tissue mechanical properties for the new regenerate tissue formation. MDPI 2018-03-23 /pmc/articles/PMC5923389/ /pubmed/29570651 http://dx.doi.org/10.3390/md16040102 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Benayahu, Dafna Sharabi, Mirit Pomeraniec, Leslie Awad, Lama Haj-Ali, Rami Benayahu, Yehuda Unique Collagen Fibers for Biomedical Applications |
title | Unique Collagen Fibers for Biomedical Applications |
title_full | Unique Collagen Fibers for Biomedical Applications |
title_fullStr | Unique Collagen Fibers for Biomedical Applications |
title_full_unstemmed | Unique Collagen Fibers for Biomedical Applications |
title_short | Unique Collagen Fibers for Biomedical Applications |
title_sort | unique collagen fibers for biomedical applications |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923389/ https://www.ncbi.nlm.nih.gov/pubmed/29570651 http://dx.doi.org/10.3390/md16040102 |
work_keys_str_mv | AT benayahudafna uniquecollagenfibersforbiomedicalapplications AT sharabimirit uniquecollagenfibersforbiomedicalapplications AT pomeraniecleslie uniquecollagenfibersforbiomedicalapplications AT awadlama uniquecollagenfibersforbiomedicalapplications AT hajalirami uniquecollagenfibersforbiomedicalapplications AT benayahuyehuda uniquecollagenfibersforbiomedicalapplications |