New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54

Four new eudesmane-type sesquiterpenoids, penicieudesmol A–D (1–4), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher’s method. T...

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Detalles Bibliográficos
Autores principales: Qiu, Liuming, Wang, Pei, Liao, Ge, Zeng, Yanbo, Cai, Caihong, Kong, Fandong, Guo, Zhikai, Proksch, Peter, Dai, Haofu, Mei, Wenli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923395/
https://www.ncbi.nlm.nih.gov/pubmed/29597304
http://dx.doi.org/10.3390/md16040108
Descripción
Sumario:Four new eudesmane-type sesquiterpenoids, penicieudesmol A–D (1–4), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher’s method. The bioassays results showed that 2 exhibited weak cytotoxicity against K-562 cells.

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