New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54

Four new eudesmane-type sesquiterpenoids, penicieudesmol A–D (1–4), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher’s method. T...

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Autores principales: Qiu, Liuming, Wang, Pei, Liao, Ge, Zeng, Yanbo, Cai, Caihong, Kong, Fandong, Guo, Zhikai, Proksch, Peter, Dai, Haofu, Mei, Wenli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923395/
https://www.ncbi.nlm.nih.gov/pubmed/29597304
http://dx.doi.org/10.3390/md16040108
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author Qiu, Liuming
Wang, Pei
Liao, Ge
Zeng, Yanbo
Cai, Caihong
Kong, Fandong
Guo, Zhikai
Proksch, Peter
Dai, Haofu
Mei, Wenli
author_facet Qiu, Liuming
Wang, Pei
Liao, Ge
Zeng, Yanbo
Cai, Caihong
Kong, Fandong
Guo, Zhikai
Proksch, Peter
Dai, Haofu
Mei, Wenli
author_sort Qiu, Liuming
collection PubMed
description Four new eudesmane-type sesquiterpenoids, penicieudesmol A–D (1–4), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher’s method. The bioassays results showed that 2 exhibited weak cytotoxicity against K-562 cells.
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spelling pubmed-59233952018-05-03 New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54 Qiu, Liuming Wang, Pei Liao, Ge Zeng, Yanbo Cai, Caihong Kong, Fandong Guo, Zhikai Proksch, Peter Dai, Haofu Mei, Wenli Mar Drugs Article Four new eudesmane-type sesquiterpenoids, penicieudesmol A–D (1–4), were isolated from the fermentation broth of the mangrove-derived endophytic fungus Penicillium sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher’s method. The bioassays results showed that 2 exhibited weak cytotoxicity against K-562 cells. MDPI 2018-03-28 /pmc/articles/PMC5923395/ /pubmed/29597304 http://dx.doi.org/10.3390/md16040108 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Qiu, Liuming
Wang, Pei
Liao, Ge
Zeng, Yanbo
Cai, Caihong
Kong, Fandong
Guo, Zhikai
Proksch, Peter
Dai, Haofu
Mei, Wenli
New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54
title New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54
title_full New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54
title_fullStr New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54
title_full_unstemmed New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54
title_short New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54
title_sort new eudesmane-type sesquiterpenoids from the mangrove-derived endophytic fungus penicillium sp. j-54
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923395/
https://www.ncbi.nlm.nih.gov/pubmed/29597304
http://dx.doi.org/10.3390/md16040108
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