Makaluvamine G from the Marine Sponge Zyzzia fuliginosa Inhibits Muscle nAChR by Binding at the Orthosteric and Allosteric Sites

Diverse ligands of the muscle nicotinic acetylcholine receptor (nAChR) are used as muscle relaxants during surgery. Although a plethora of such molecules exists in the market, there is still a need for new drugs with rapid on/off-set, increased selectivity, and so forth. We found that pyrroloiminoqu...

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Detalles Bibliográficos
Autores principales: Kudryavtsev, Denis S., Spirova, Ekaterina N., Shelukhina, Irina V., Son, Lina V., Makarova, Yana V., Utkina, Natalia K., Kasheverov, Igor E., Tsetlin, Victor I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923396/
https://www.ncbi.nlm.nih.gov/pubmed/29597332
http://dx.doi.org/10.3390/md16040109

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