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Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods

A diverse range of predatory marine gastropods produce toxins, yet most of these molecules remain uncharacterized. Conus species have received the most attention from researchers, leading to several conopeptides reaching clinical trials. This review aims to summarize what is known about bioactive co...

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Detalles Bibliográficos
Autores principales: Turner, Ashlin H., Craik, David J., Kaas, Quentin, Schroeder, Christina I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923405/
https://www.ncbi.nlm.nih.gov/pubmed/29621159
http://dx.doi.org/10.3390/md16040118
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author Turner, Ashlin H.
Craik, David J.
Kaas, Quentin
Schroeder, Christina I.
author_facet Turner, Ashlin H.
Craik, David J.
Kaas, Quentin
Schroeder, Christina I.
author_sort Turner, Ashlin H.
collection PubMed
description A diverse range of predatory marine gastropods produce toxins, yet most of these molecules remain uncharacterized. Conus species have received the most attention from researchers, leading to several conopeptides reaching clinical trials. This review aims to summarize what is known about bioactive compounds isolated from species of neglected marine gastropods, especially in the Turridae, Terebridae, Babyloniidae, Muricidae, Buccinidae, Colubrariidae, Nassariidae, Cassidae, and Ranellidae families. Multiple species have been reported to contain bioactive compounds with potential toxic activity, but most of these compounds have not been characterized or even clearly identified. The bioactive properties and potential applications of echotoxins and related porins from the Ranellidae family are discussed in more detail. Finally, the review concludes with a call for research on understudied species.
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spelling pubmed-59234052018-05-03 Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods Turner, Ashlin H. Craik, David J. Kaas, Quentin Schroeder, Christina I. Mar Drugs Review A diverse range of predatory marine gastropods produce toxins, yet most of these molecules remain uncharacterized. Conus species have received the most attention from researchers, leading to several conopeptides reaching clinical trials. This review aims to summarize what is known about bioactive compounds isolated from species of neglected marine gastropods, especially in the Turridae, Terebridae, Babyloniidae, Muricidae, Buccinidae, Colubrariidae, Nassariidae, Cassidae, and Ranellidae families. Multiple species have been reported to contain bioactive compounds with potential toxic activity, but most of these compounds have not been characterized or even clearly identified. The bioactive properties and potential applications of echotoxins and related porins from the Ranellidae family are discussed in more detail. Finally, the review concludes with a call for research on understudied species. MDPI 2018-04-05 /pmc/articles/PMC5923405/ /pubmed/29621159 http://dx.doi.org/10.3390/md16040118 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Turner, Ashlin H.
Craik, David J.
Kaas, Quentin
Schroeder, Christina I.
Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods
title Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods
title_full Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods
title_fullStr Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods
title_full_unstemmed Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods
title_short Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods
title_sort bioactive compounds isolated from neglected predatory marine gastropods
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923405/
https://www.ncbi.nlm.nih.gov/pubmed/29621159
http://dx.doi.org/10.3390/md16040118
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