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Holotoxin A(1) Induces Apoptosis by Activating Acid Sphingomyelinase and Neutral Sphingomyelinase in K562 and Human Primary Leukemia Cells

Marine triterpene glycosides are attractive candidates for the development of anticancer agents. Holotoxin A(1) is a triterpene glycoside found in the edible sea cucumber, Apostichopus (Stichopus) japonicus. We previously showed that cladoloside C(2), the 25(26)-dihydro derivative of holotoxin A(1),...

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Detalles Bibliográficos
Autores principales:	Yun, Seong-Hoon, Sim, Eun-Hye, Han, Sang-Heum, Han, Jin-Yeong, Kim, Sung-Hyun, Silchenko, Alexandra S., Stonik, Valentin A., Park, Joo-In
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923410/ https://www.ncbi.nlm.nih.gov/pubmed/29642569 http://dx.doi.org/10.3390/md16040123

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