Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment

Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the abs...

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Detalles Bibliográficos
Autores principales: Kim, Dayoung, Lee, Eun Ju, Lee, Jihye, Leutou, Alain S., Shin, Yern-Hyerk, Choi, Bomi, Hwang, Ji Sun, Hahn, Dongyup, Choi, Hyukjae, Chin, Jungwook, Cho, Sung Jin, Hong, Yong Deog, Ko, Jaeyoung, Seong, Chi Nam, Maloney, Katherine N., Oh, Dong-Chan, Yang, Inho, Hwang, Hayoung, Nam, Sang-Jip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923417/
https://www.ncbi.nlm.nih.gov/pubmed/29659509
http://dx.doi.org/10.3390/md16040130
Descripción
Sumario:Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.

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