Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment

Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the abs...

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Autores principales: Kim, Dayoung, Lee, Eun Ju, Lee, Jihye, Leutou, Alain S., Shin, Yern-Hyerk, Choi, Bomi, Hwang, Ji Sun, Hahn, Dongyup, Choi, Hyukjae, Chin, Jungwook, Cho, Sung Jin, Hong, Yong Deog, Ko, Jaeyoung, Seong, Chi Nam, Maloney, Katherine N., Oh, Dong-Chan, Yang, Inho, Hwang, Hayoung, Nam, Sang-Jip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923417/
https://www.ncbi.nlm.nih.gov/pubmed/29659509
http://dx.doi.org/10.3390/md16040130
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author Kim, Dayoung
Lee, Eun Ju
Lee, Jihye
Leutou, Alain S.
Shin, Yern-Hyerk
Choi, Bomi
Hwang, Ji Sun
Hahn, Dongyup
Choi, Hyukjae
Chin, Jungwook
Cho, Sung Jin
Hong, Yong Deog
Ko, Jaeyoung
Seong, Chi Nam
Maloney, Katherine N.
Oh, Dong-Chan
Yang, Inho
Hwang, Hayoung
Nam, Sang-Jip
author_facet Kim, Dayoung
Lee, Eun Ju
Lee, Jihye
Leutou, Alain S.
Shin, Yern-Hyerk
Choi, Bomi
Hwang, Ji Sun
Hahn, Dongyup
Choi, Hyukjae
Chin, Jungwook
Cho, Sung Jin
Hong, Yong Deog
Ko, Jaeyoung
Seong, Chi Nam
Maloney, Katherine N.
Oh, Dong-Chan
Yang, Inho
Hwang, Hayoung
Nam, Sang-Jip
author_sort Kim, Dayoung
collection PubMed
description Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase.
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spelling pubmed-59234172018-05-03 Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment Kim, Dayoung Lee, Eun Ju Lee, Jihye Leutou, Alain S. Shin, Yern-Hyerk Choi, Bomi Hwang, Ji Sun Hahn, Dongyup Choi, Hyukjae Chin, Jungwook Cho, Sung Jin Hong, Yong Deog Ko, Jaeyoung Seong, Chi Nam Maloney, Katherine N. Oh, Dong-Chan Yang, Inho Hwang, Hayoung Nam, Sang-Jip Mar Drugs Article Antartin (1), a new zizaane-type sesquiterpene, was isolated from Streptomyces sp. SCO736. The chemical structure of 1 was assigned from the interpretation of 1D and 2D NMR in addition to mass spectrometric data. The relative stereochemistry of 1 was determined by analysis of NOE data, while the absolute stereochemistry was decided based on a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Antartin (1) showed cytotoxicity against A549, H1299, and U87 cancer cell lines by causing cell cycle arrest at the G1 phase. MDPI 2018-04-16 /pmc/articles/PMC5923417/ /pubmed/29659509 http://dx.doi.org/10.3390/md16040130 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Dayoung
Lee, Eun Ju
Lee, Jihye
Leutou, Alain S.
Shin, Yern-Hyerk
Choi, Bomi
Hwang, Ji Sun
Hahn, Dongyup
Choi, Hyukjae
Chin, Jungwook
Cho, Sung Jin
Hong, Yong Deog
Ko, Jaeyoung
Seong, Chi Nam
Maloney, Katherine N.
Oh, Dong-Chan
Yang, Inho
Hwang, Hayoung
Nam, Sang-Jip
Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment
title Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment
title_full Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment
title_fullStr Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment
title_full_unstemmed Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment
title_short Antartin, a Cytotoxic Zizaane-Type Sesquiterpenoid from a Streptomyces sp. Isolated from an Antarctic Marine Sediment
title_sort antartin, a cytotoxic zizaane-type sesquiterpenoid from a streptomyces sp. isolated from an antarctic marine sediment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923417/
https://www.ncbi.nlm.nih.gov/pubmed/29659509
http://dx.doi.org/10.3390/md16040130
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