Mutations in the Non-Structural Protein-Coding Sequence of Protoparvovirus H-1PV Enhance the Fitness of the Virus and Show Key Benefits Regarding the Transduction Efficiency of Derived Vectors

Single nucleotide changes were introduced into the non-structural (NS) coding sequence of the H-1 parvovirus (PV) infectious molecular clone and the corresponding virus stocks produced, thereby generating H1-PM-I, H1-PM-II, H1-PM-III, and H1-DM. The effects of the mutations on viral fitness were ana...

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Detalles Bibliográficos
Autores principales: Hashemi, Hamidreza, Condurat, Alexandra-Larisa, Stroh-Dege, Alexandra, Weiss, Nadine, Geiss, Carsten, Pilet, Jill, Cornet Bartolomé, Carles, Rommelaere, Jean, Salomé, Nathalie, Dinsart, Christiane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923444/
https://www.ncbi.nlm.nih.gov/pubmed/29584637
http://dx.doi.org/10.3390/v10040150

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