Advances in HIV-1 Vaccine Development

An efficacious HIV-1 vaccine is regarded as the best way to halt the ongoing HIV-1 epidemic. However, despite significant efforts to develop a safe and effective vaccine, the modestly protective RV144 trial remains the only efficacy trial to provide some level of protection against HIV-1 acquisition...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Yong, McKay, Paul F., Mann, Jamie F. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923461/
https://www.ncbi.nlm.nih.gov/pubmed/29614779
http://dx.doi.org/10.3390/v10040167
_version_ 1783318347003199488
author Gao, Yong
McKay, Paul F.
Mann, Jamie F. S.
author_facet Gao, Yong
McKay, Paul F.
Mann, Jamie F. S.
author_sort Gao, Yong
collection PubMed
description An efficacious HIV-1 vaccine is regarded as the best way to halt the ongoing HIV-1 epidemic. However, despite significant efforts to develop a safe and effective vaccine, the modestly protective RV144 trial remains the only efficacy trial to provide some level of protection against HIV-1 acquisition. This review will outline the history of HIV vaccine development, novel technologies being applied to HIV vaccinology and immunogen design, as well as the studies that are ongoing to advance our understanding of vaccine-induced immune correlates of protection.
format Online
Article
Text
id pubmed-5923461
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-59234612018-05-03 Advances in HIV-1 Vaccine Development Gao, Yong McKay, Paul F. Mann, Jamie F. S. Viruses Review An efficacious HIV-1 vaccine is regarded as the best way to halt the ongoing HIV-1 epidemic. However, despite significant efforts to develop a safe and effective vaccine, the modestly protective RV144 trial remains the only efficacy trial to provide some level of protection against HIV-1 acquisition. This review will outline the history of HIV vaccine development, novel technologies being applied to HIV vaccinology and immunogen design, as well as the studies that are ongoing to advance our understanding of vaccine-induced immune correlates of protection. MDPI 2018-04-01 /pmc/articles/PMC5923461/ /pubmed/29614779 http://dx.doi.org/10.3390/v10040167 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gao, Yong
McKay, Paul F.
Mann, Jamie F. S.
Advances in HIV-1 Vaccine Development
title Advances in HIV-1 Vaccine Development
title_full Advances in HIV-1 Vaccine Development
title_fullStr Advances in HIV-1 Vaccine Development
title_full_unstemmed Advances in HIV-1 Vaccine Development
title_short Advances in HIV-1 Vaccine Development
title_sort advances in hiv-1 vaccine development
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923461/
https://www.ncbi.nlm.nih.gov/pubmed/29614779
http://dx.doi.org/10.3390/v10040167
work_keys_str_mv AT gaoyong advancesinhiv1vaccinedevelopment
AT mckaypaulf advancesinhiv1vaccinedevelopment
AT mannjamiefs advancesinhiv1vaccinedevelopment

Ejemplares similares