CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells

Hepatitis C virus (HCV) enters human hepatocytes using four essential entry factors, one of which is human CD81 (hCD81). The tetraspanin hCD81 contains a large extracellular loop (LEL), which interacts with the E2 glycoprotein of HCV. The role of the non-LEL regions of hCD81 (intracellular tails, fo...

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Detalles Bibliográficos
Autores principales: Banse, Pia, Moeller, Rebecca, Bruening, Janina, Lasswitz, Lisa, Kahl, Sina, Khan, Abdul G., Marcotrigiano, Joseph, Pietschmann, Thomas, Gerold, Gisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923501/
https://www.ncbi.nlm.nih.gov/pubmed/29677132
http://dx.doi.org/10.3390/v10040207

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