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Cardiovascular-Related Outcomes in U.S. Adults Exposed to Lead

Cardiovascular-related clinical markers were evaluated in this cross-sectional study of United States adults (aged ≥ 20) exposed to lead via the National Health and Nutrition Examination Survey 2007–2008 and the 2009–2010 datasets. In four quartiles of exposure—0–2 μg/dL, 2–5 μg/dL, 5–10 μg/dL, and...

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Autores principales: Obeng-Gyasi, Emmanuel, Armijos, Rodrigo X., Weigel, M. Margaret, Filippelli, Gabriel M., Sayegh, M. Aaron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923801/
https://www.ncbi.nlm.nih.gov/pubmed/29662032
http://dx.doi.org/10.3390/ijerph15040759
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author Obeng-Gyasi, Emmanuel
Armijos, Rodrigo X.
Weigel, M. Margaret
Filippelli, Gabriel M.
Sayegh, M. Aaron
author_facet Obeng-Gyasi, Emmanuel
Armijos, Rodrigo X.
Weigel, M. Margaret
Filippelli, Gabriel M.
Sayegh, M. Aaron
author_sort Obeng-Gyasi, Emmanuel
collection PubMed
description Cardiovascular-related clinical markers were evaluated in this cross-sectional study of United States adults (aged ≥ 20) exposed to lead via the National Health and Nutrition Examination Survey 2007–2008 and the 2009–2010 datasets. In four quartiles of exposure—0–2 μg/dL, 2–5 μg/dL, 5–10 μg/dL, and 10 μg/dL and over, clinical and anthropometric markers were evaluated—to examine how the markers manifested in the quartiles. Associations were determined via linear regression. Finally, clinical makers, and how they manifested between exposed and less-exposed occupations, were explored in addition to how duration of exposure altered these clinical markers. In regression analysis, Diastolic Blood Pressure (DBP) and high-density lipoprotein (HDL) cholesterol, were significantly associated with blood lead level (BLL). In the occupational analysis, Systolic Blood Pressure (SBP), DBP, C-reactive protein (CRP), triglycerides, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, showed differences between populations in the exposed and less-exposed occupations. Regarding Agriculture, Forestry & Fishing, the duration of exposure altered SBP, CRP, and LDL cholesterol. With mining, the duration of exposure altered SBP, DBP, triglycerides, and HDL cholesterol, whereas in construction, the duration in occupation altered SBP, triglycerides, and CRP. In conclusion, lead exposure has a profound effect on the cardiovascular system, with potentially adverse outcomes existing at all exposure levels.
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spelling pubmed-59238012018-05-03 Cardiovascular-Related Outcomes in U.S. Adults Exposed to Lead Obeng-Gyasi, Emmanuel Armijos, Rodrigo X. Weigel, M. Margaret Filippelli, Gabriel M. Sayegh, M. Aaron Int J Environ Res Public Health Article Cardiovascular-related clinical markers were evaluated in this cross-sectional study of United States adults (aged ≥ 20) exposed to lead via the National Health and Nutrition Examination Survey 2007–2008 and the 2009–2010 datasets. In four quartiles of exposure—0–2 μg/dL, 2–5 μg/dL, 5–10 μg/dL, and 10 μg/dL and over, clinical and anthropometric markers were evaluated—to examine how the markers manifested in the quartiles. Associations were determined via linear regression. Finally, clinical makers, and how they manifested between exposed and less-exposed occupations, were explored in addition to how duration of exposure altered these clinical markers. In regression analysis, Diastolic Blood Pressure (DBP) and high-density lipoprotein (HDL) cholesterol, were significantly associated with blood lead level (BLL). In the occupational analysis, Systolic Blood Pressure (SBP), DBP, C-reactive protein (CRP), triglycerides, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, showed differences between populations in the exposed and less-exposed occupations. Regarding Agriculture, Forestry & Fishing, the duration of exposure altered SBP, CRP, and LDL cholesterol. With mining, the duration of exposure altered SBP, DBP, triglycerides, and HDL cholesterol, whereas in construction, the duration in occupation altered SBP, triglycerides, and CRP. In conclusion, lead exposure has a profound effect on the cardiovascular system, with potentially adverse outcomes existing at all exposure levels. MDPI 2018-04-15 2018-04 /pmc/articles/PMC5923801/ /pubmed/29662032 http://dx.doi.org/10.3390/ijerph15040759 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Obeng-Gyasi, Emmanuel
Armijos, Rodrigo X.
Weigel, M. Margaret
Filippelli, Gabriel M.
Sayegh, M. Aaron
Cardiovascular-Related Outcomes in U.S. Adults Exposed to Lead
title Cardiovascular-Related Outcomes in U.S. Adults Exposed to Lead
title_full Cardiovascular-Related Outcomes in U.S. Adults Exposed to Lead
title_fullStr Cardiovascular-Related Outcomes in U.S. Adults Exposed to Lead
title_full_unstemmed Cardiovascular-Related Outcomes in U.S. Adults Exposed to Lead
title_short Cardiovascular-Related Outcomes in U.S. Adults Exposed to Lead
title_sort cardiovascular-related outcomes in u.s. adults exposed to lead
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923801/
https://www.ncbi.nlm.nih.gov/pubmed/29662032
http://dx.doi.org/10.3390/ijerph15040759
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