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Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy
Background: Urinary cotinine, a metabolite of nicotine, is a marker of tobacco smoke exposure. A cutoff value for cotinine concentration can be set to distinguish smokers from non-smokers, independently from self-declared status. Method: Cotinine was determined by isotopic dilution High Performance...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923846/ https://www.ncbi.nlm.nih.gov/pubmed/29671826 http://dx.doi.org/10.3390/ijerph15040804 |
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author | Paci, Enrico Pigini, Daniela Bauleo, Lisa Ancona, Carla Forastiere, Francesco Tranfo, Giovanna |
author_facet | Paci, Enrico Pigini, Daniela Bauleo, Lisa Ancona, Carla Forastiere, Francesco Tranfo, Giovanna |
author_sort | Paci, Enrico |
collection | PubMed |
description | Background: Urinary cotinine, a metabolite of nicotine, is a marker of tobacco smoke exposure. A cutoff value for cotinine concentration can be set to distinguish smokers from non-smokers, independently from self-declared status. Method: Cotinine was determined by isotopic dilution High Performance Liquid Chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) between 2013 and 2014 on urine samples of a population of 1075 subjects. Results: 296 subjects have a cotinine level higher than 100 μg/g of creatinine (cutoff), with a median cotinine concentration of 1504.70 μg/g of creatinine. The mean is 27.5% of smokers and 60.5% in this group are females. The median value for non-smokers is 5.6 μg/g of creatinine. Two hundred and seventy-five subjects declared to be smokers in the questionnaire, but 6 (2.2%) present urinary cotinine levels lower than cutoff; 800 subjects declared to be non-smokers, but 26 of them presented urinary cotinine levels that were higher than the cutoff (3.3%). Conclusion: Using the cutoff of 100 μg/g, the misclassification of smokers resulted to be 2.2%, indicating that the selected value is suitable for studying the human exposures to environmental and occupational pollutants, including those produced by smoking. |
format | Online Article Text |
id | pubmed-5923846 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59238462018-05-03 Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy Paci, Enrico Pigini, Daniela Bauleo, Lisa Ancona, Carla Forastiere, Francesco Tranfo, Giovanna Int J Environ Res Public Health Article Background: Urinary cotinine, a metabolite of nicotine, is a marker of tobacco smoke exposure. A cutoff value for cotinine concentration can be set to distinguish smokers from non-smokers, independently from self-declared status. Method: Cotinine was determined by isotopic dilution High Performance Liquid Chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) between 2013 and 2014 on urine samples of a population of 1075 subjects. Results: 296 subjects have a cotinine level higher than 100 μg/g of creatinine (cutoff), with a median cotinine concentration of 1504.70 μg/g of creatinine. The mean is 27.5% of smokers and 60.5% in this group are females. The median value for non-smokers is 5.6 μg/g of creatinine. Two hundred and seventy-five subjects declared to be smokers in the questionnaire, but 6 (2.2%) present urinary cotinine levels lower than cutoff; 800 subjects declared to be non-smokers, but 26 of them presented urinary cotinine levels that were higher than the cutoff (3.3%). Conclusion: Using the cutoff of 100 μg/g, the misclassification of smokers resulted to be 2.2%, indicating that the selected value is suitable for studying the human exposures to environmental and occupational pollutants, including those produced by smoking. MDPI 2018-04-19 2018-04 /pmc/articles/PMC5923846/ /pubmed/29671826 http://dx.doi.org/10.3390/ijerph15040804 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Paci, Enrico Pigini, Daniela Bauleo, Lisa Ancona, Carla Forastiere, Francesco Tranfo, Giovanna Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy |
title | Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy |
title_full | Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy |
title_fullStr | Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy |
title_full_unstemmed | Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy |
title_short | Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy |
title_sort | urinary cotinine concentration and self-reported smoking status in 1075 subjects living in central italy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5923846/ https://www.ncbi.nlm.nih.gov/pubmed/29671826 http://dx.doi.org/10.3390/ijerph15040804 |
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