A randomized trial to study the comparative efficacy of phenylbutyrate and benzoate on nitrogen excretion and ureagenesis in healthy volunteers

PURPOSE: Benzoate and phenylbutyrate are widely used in the treatment of urea cycle disorders, but detailed studies on pharmacokinetics and comparative efficacy on nitrogen excretion are lacking. METHODS: We conducted a randomized, three arm, crossover trial in healthy volunteers to study pharmacoki...

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Detalles Bibliográficos
Autores principales: Nagamani, Sandesh C.S., Agarwal, Umang, Tam, Allison, Azamian, Mahshid, McMeans, Ann, Didelija, Inka C., Mohammad, Mahmoud A., Marini, Juan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924481/
https://www.ncbi.nlm.nih.gov/pubmed/29693650
http://dx.doi.org/10.1038/gim.2017.167

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