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Is There Still Any Role for Oxidative Stress in Mitochondrial DNA-Dependent Aging?

Recent deep sequencing data has provided compelling evidence that the spectrum of somatic point mutations in mitochondrial DNA (mtDNA) in aging tissues lacks G > T transversion mutations. This fact cannot, however, be used as an argument for the missing contribution of reactive oxygen species (RO...

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Detalles Bibliográficos
Autores principales:	Zsurka, Gábor, Peeva, Viktoriya, Kotlyar, Alexander, Kunz, Wolfram S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924517/ https://www.ncbi.nlm.nih.gov/pubmed/29561808 http://dx.doi.org/10.3390/genes9040175

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