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TRAP1 Regulation of Cancer Metabolism: Dual Role as Oncogene or Tumor Suppressor
Metabolic reprogramming is an important issue in tumor biology. An unexpected inter- and intra-tumor metabolic heterogeneity has been strictly correlated to tumor outcome. Tumor Necrosis Factor Receptor-Associated Protein 1 (TRAP1) is a molecular chaperone involved in the regulation of energetic met...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924537/ https://www.ncbi.nlm.nih.gov/pubmed/29621137 http://dx.doi.org/10.3390/genes9040195 |
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author | Matassa, Danilo Swann Agliarulo, Ilenia Avolio, Rosario Landriscina, Matteo Esposito, Franca |
author_facet | Matassa, Danilo Swann Agliarulo, Ilenia Avolio, Rosario Landriscina, Matteo Esposito, Franca |
author_sort | Matassa, Danilo Swann |
collection | PubMed |
description | Metabolic reprogramming is an important issue in tumor biology. An unexpected inter- and intra-tumor metabolic heterogeneity has been strictly correlated to tumor outcome. Tumor Necrosis Factor Receptor-Associated Protein 1 (TRAP1) is a molecular chaperone involved in the regulation of energetic metabolism in cancer cells. This protein is highly expressed in several cancers, such as glioblastoma, colon, breast, prostate and lung cancers and is often associated with drug resistance. However, TRAP1 is also downregulated in specific tumors, such as ovarian, bladder and renal cancers, where its lower expression is correlated with the worst prognoses and chemoresistance. TRAP1 is the only mitochondrial member of the Heat Shock Protein 90 (HSP90) family that directly interacts with respiratory complexes, contributing to their stability and activity but it is still unclear if such interactions lead to reduced or increased respiratory capacity. The role of TRAP1 is to enhance or suppress oxidative phosphorylation; the effects of such regulation on tumor development and progression are controversial. These observations encourage the study of the mechanisms responsible for the dualist role of TRAP1 as an oncogene or oncosuppressor in specific tumor types. In this review, TRAP1 puzzling functions were recapitulated with a special focus on the correlation between metabolic reprogramming and tumor outcome. We wanted to investigate whether metabolism-targeting drugs can efficiently interfere with tumor progression and whether they might be combined with chemotherapeutics or molecular-targeted agents to counteract drug resistance and reduce therapeutic failure. |
format | Online Article Text |
id | pubmed-5924537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59245372018-05-03 TRAP1 Regulation of Cancer Metabolism: Dual Role as Oncogene or Tumor Suppressor Matassa, Danilo Swann Agliarulo, Ilenia Avolio, Rosario Landriscina, Matteo Esposito, Franca Genes (Basel) Review Metabolic reprogramming is an important issue in tumor biology. An unexpected inter- and intra-tumor metabolic heterogeneity has been strictly correlated to tumor outcome. Tumor Necrosis Factor Receptor-Associated Protein 1 (TRAP1) is a molecular chaperone involved in the regulation of energetic metabolism in cancer cells. This protein is highly expressed in several cancers, such as glioblastoma, colon, breast, prostate and lung cancers and is often associated with drug resistance. However, TRAP1 is also downregulated in specific tumors, such as ovarian, bladder and renal cancers, where its lower expression is correlated with the worst prognoses and chemoresistance. TRAP1 is the only mitochondrial member of the Heat Shock Protein 90 (HSP90) family that directly interacts with respiratory complexes, contributing to their stability and activity but it is still unclear if such interactions lead to reduced or increased respiratory capacity. The role of TRAP1 is to enhance or suppress oxidative phosphorylation; the effects of such regulation on tumor development and progression are controversial. These observations encourage the study of the mechanisms responsible for the dualist role of TRAP1 as an oncogene or oncosuppressor in specific tumor types. In this review, TRAP1 puzzling functions were recapitulated with a special focus on the correlation between metabolic reprogramming and tumor outcome. We wanted to investigate whether metabolism-targeting drugs can efficiently interfere with tumor progression and whether they might be combined with chemotherapeutics or molecular-targeted agents to counteract drug resistance and reduce therapeutic failure. MDPI 2018-04-05 /pmc/articles/PMC5924537/ /pubmed/29621137 http://dx.doi.org/10.3390/genes9040195 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Matassa, Danilo Swann Agliarulo, Ilenia Avolio, Rosario Landriscina, Matteo Esposito, Franca TRAP1 Regulation of Cancer Metabolism: Dual Role as Oncogene or Tumor Suppressor |
title | TRAP1 Regulation of Cancer Metabolism: Dual Role as Oncogene or Tumor Suppressor |
title_full | TRAP1 Regulation of Cancer Metabolism: Dual Role as Oncogene or Tumor Suppressor |
title_fullStr | TRAP1 Regulation of Cancer Metabolism: Dual Role as Oncogene or Tumor Suppressor |
title_full_unstemmed | TRAP1 Regulation of Cancer Metabolism: Dual Role as Oncogene or Tumor Suppressor |
title_short | TRAP1 Regulation of Cancer Metabolism: Dual Role as Oncogene or Tumor Suppressor |
title_sort | trap1 regulation of cancer metabolism: dual role as oncogene or tumor suppressor |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924537/ https://www.ncbi.nlm.nih.gov/pubmed/29621137 http://dx.doi.org/10.3390/genes9040195 |
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