Wnt Signaling in Thyroid Homeostasis and Carcinogenesis

The Wnt pathway is essential for stem cell maintenance, but little is known about its role in thyroid hormone signaling and thyroid stem cell survival and maintenance. In addition, the role of Wnt signaling in thyroid cancer progenitor cells is also unclear. Here, we present emerging evidence for th...

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Detalles Bibliográficos
Autores principales: Ely, Kim A., Bischoff, Lindsay A., Weiss, Vivian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924546/
https://www.ncbi.nlm.nih.gov/pubmed/29642644
http://dx.doi.org/10.3390/genes9040204
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author Ely, Kim A.
Bischoff, Lindsay A.
Weiss, Vivian L.
author_facet Ely, Kim A.
Bischoff, Lindsay A.
Weiss, Vivian L.
author_sort Ely, Kim A.
collection PubMed
description The Wnt pathway is essential for stem cell maintenance, but little is known about its role in thyroid hormone signaling and thyroid stem cell survival and maintenance. In addition, the role of Wnt signaling in thyroid cancer progenitor cells is also unclear. Here, we present emerging evidence for the role of Wnt signaling in somatic thyroid stem cell and thyroid cancer stem cell function. An improved understanding of the role of Wnt signaling in thyroid physiology and carcinogenesis is essential for improving both thyroid disease diagnostics and therapeutics.
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spelling pubmed-59245462018-05-03 Wnt Signaling in Thyroid Homeostasis and Carcinogenesis Ely, Kim A. Bischoff, Lindsay A. Weiss, Vivian L. Genes (Basel) Review The Wnt pathway is essential for stem cell maintenance, but little is known about its role in thyroid hormone signaling and thyroid stem cell survival and maintenance. In addition, the role of Wnt signaling in thyroid cancer progenitor cells is also unclear. Here, we present emerging evidence for the role of Wnt signaling in somatic thyroid stem cell and thyroid cancer stem cell function. An improved understanding of the role of Wnt signaling in thyroid physiology and carcinogenesis is essential for improving both thyroid disease diagnostics and therapeutics. MDPI 2018-04-10 /pmc/articles/PMC5924546/ /pubmed/29642644 http://dx.doi.org/10.3390/genes9040204 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ely, Kim A.
Bischoff, Lindsay A.
Weiss, Vivian L.
Wnt Signaling in Thyroid Homeostasis and Carcinogenesis
title Wnt Signaling in Thyroid Homeostasis and Carcinogenesis
title_full Wnt Signaling in Thyroid Homeostasis and Carcinogenesis
title_fullStr Wnt Signaling in Thyroid Homeostasis and Carcinogenesis
title_full_unstemmed Wnt Signaling in Thyroid Homeostasis and Carcinogenesis
title_short Wnt Signaling in Thyroid Homeostasis and Carcinogenesis
title_sort wnt signaling in thyroid homeostasis and carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924546/
https://www.ncbi.nlm.nih.gov/pubmed/29642644
http://dx.doi.org/10.3390/genes9040204
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