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Pharmacological activation of REV-ERBs is lethal in cancer and oncogene induced senescence

The circadian clock imposes daily rhythms in cell proliferation, metabolism, inflammation and DNA damage response(1, 2). Perturbations of these processes are hallmarks of cancer(3) and chronic circadian rhythm disruption predisposes to tumor development(1, 4). This raises the hypothesis that pharmac...

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Detalles Bibliográficos
Autores principales:	Sulli, Gabriele, Rommel, Amy, Wang, Xiaojie, Kolar, Matthew J., Puca, Francesca, Saghatelian, Alan, Plikus, Maksim V., Verma, Inder M., Panda, Satchidananda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924733/ https://www.ncbi.nlm.nih.gov/pubmed/29320480 http://dx.doi.org/10.1038/nature25170

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