The Hunt for the Source of Primary Interleukin-4: How We Discovered That Natural Killer T Cells and Basophils Determine T Helper Type 2 Cell Differentiation In Vivo

Interleukin (IL)-4 plays a central role in determining the phenotype of naïve CD4(+) T cells by promoting their differentiation into IL-4-producing T helper type 2 (Th2) cells, which are crucial for the induction of allergic inflammation. However, to date, the potential sources of “primary IL-4” in...

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Autor principal: Yoshimoto, Tomohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924770/
https://www.ncbi.nlm.nih.gov/pubmed/29740428
http://dx.doi.org/10.3389/fimmu.2018.00716
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author Yoshimoto, Tomohiro
author_facet Yoshimoto, Tomohiro
author_sort Yoshimoto, Tomohiro
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description Interleukin (IL)-4 plays a central role in determining the phenotype of naïve CD4(+) T cells by promoting their differentiation into IL-4-producing T helper type 2 (Th2) cells, which are crucial for the induction of allergic inflammation. However, to date, the potential sources of “primary IL-4” in vivo, as distinguished from IL-4 produced by Th2 cells, remain unclear. Here, I describe the research I carried out in collaboration with Dr. William E. Paul to identify “primary IL-4”-producing cells and Th2 cell differentiation in vivo.
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spelling pubmed-59247702018-05-08 The Hunt for the Source of Primary Interleukin-4: How We Discovered That Natural Killer T Cells and Basophils Determine T Helper Type 2 Cell Differentiation In Vivo Yoshimoto, Tomohiro Front Immunol Immunology Interleukin (IL)-4 plays a central role in determining the phenotype of naïve CD4(+) T cells by promoting their differentiation into IL-4-producing T helper type 2 (Th2) cells, which are crucial for the induction of allergic inflammation. However, to date, the potential sources of “primary IL-4” in vivo, as distinguished from IL-4 produced by Th2 cells, remain unclear. Here, I describe the research I carried out in collaboration with Dr. William E. Paul to identify “primary IL-4”-producing cells and Th2 cell differentiation in vivo. Frontiers Media S.A. 2018-04-23 /pmc/articles/PMC5924770/ /pubmed/29740428 http://dx.doi.org/10.3389/fimmu.2018.00716 Text en Copyright © 2018 Yoshimoto. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yoshimoto, Tomohiro
The Hunt for the Source of Primary Interleukin-4: How We Discovered That Natural Killer T Cells and Basophils Determine T Helper Type 2 Cell Differentiation In Vivo
title The Hunt for the Source of Primary Interleukin-4: How We Discovered That Natural Killer T Cells and Basophils Determine T Helper Type 2 Cell Differentiation In Vivo
title_full The Hunt for the Source of Primary Interleukin-4: How We Discovered That Natural Killer T Cells and Basophils Determine T Helper Type 2 Cell Differentiation In Vivo
title_fullStr The Hunt for the Source of Primary Interleukin-4: How We Discovered That Natural Killer T Cells and Basophils Determine T Helper Type 2 Cell Differentiation In Vivo
title_full_unstemmed The Hunt for the Source of Primary Interleukin-4: How We Discovered That Natural Killer T Cells and Basophils Determine T Helper Type 2 Cell Differentiation In Vivo
title_short The Hunt for the Source of Primary Interleukin-4: How We Discovered That Natural Killer T Cells and Basophils Determine T Helper Type 2 Cell Differentiation In Vivo
title_sort hunt for the source of primary interleukin-4: how we discovered that natural killer t cells and basophils determine t helper type 2 cell differentiation in vivo
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924770/
https://www.ncbi.nlm.nih.gov/pubmed/29740428
http://dx.doi.org/10.3389/fimmu.2018.00716
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