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Role of bile acids in inflammatory bowel disease

Bile acids (BAs) are the end product of cholesterol catabolism. Their synthesis is regulated by the nuclear receptor farnesoid X receptor, also involved in the control of their enterohepatic circulation. Inflammatory bowel diseases (IBD), which include Crohn’s disease (CD) and ulcerative colitis (UC...

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Autores principales: Tiratterra, Elisa, Franco, Placido, Porru, Emanuele, Katsanos, Konstantinos H., Christodoulou, Dimitrios K., Roda, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hellenic Society of Gastroenterology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924848/
https://www.ncbi.nlm.nih.gov/pubmed/29720851
http://dx.doi.org/10.20524/aog.2018.0239
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author Tiratterra, Elisa
Franco, Placido
Porru, Emanuele
Katsanos, Konstantinos H.
Christodoulou, Dimitrios K.
Roda, Giulia
author_facet Tiratterra, Elisa
Franco, Placido
Porru, Emanuele
Katsanos, Konstantinos H.
Christodoulou, Dimitrios K.
Roda, Giulia
author_sort Tiratterra, Elisa
collection PubMed
description Bile acids (BAs) are the end product of cholesterol catabolism. Their synthesis is regulated by the nuclear receptor farnesoid X receptor, also involved in the control of their enterohepatic circulation. Inflammatory bowel diseases (IBD), which include Crohn’s disease (CD) and ulcerative colitis (UC), are multifactorial diseases characterized by diarrhea. The pathogenesis of diarrhea in IBD is still debated. The most important factor is the inflammatory process of the intestinal wall, causing alterations of solute and water absorption/secretion, deterioration of epithelial cell integrity, disruption of the intestinal microflora homeostasis, and impairment of specific transport mechanisms within the gut (including that of BAs). In this review, we summarize the current state of the art in this area and we critically evaluate the alterations of BA metabolism in patients with CD and UC.
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spelling pubmed-59248482018-05-03 Role of bile acids in inflammatory bowel disease Tiratterra, Elisa Franco, Placido Porru, Emanuele Katsanos, Konstantinos H. Christodoulou, Dimitrios K. Roda, Giulia Ann Gastroenterol Invited Review Bile acids (BAs) are the end product of cholesterol catabolism. Their synthesis is regulated by the nuclear receptor farnesoid X receptor, also involved in the control of their enterohepatic circulation. Inflammatory bowel diseases (IBD), which include Crohn’s disease (CD) and ulcerative colitis (UC), are multifactorial diseases characterized by diarrhea. The pathogenesis of diarrhea in IBD is still debated. The most important factor is the inflammatory process of the intestinal wall, causing alterations of solute and water absorption/secretion, deterioration of epithelial cell integrity, disruption of the intestinal microflora homeostasis, and impairment of specific transport mechanisms within the gut (including that of BAs). In this review, we summarize the current state of the art in this area and we critically evaluate the alterations of BA metabolism in patients with CD and UC. Hellenic Society of Gastroenterology 2018 2018-02-14 /pmc/articles/PMC5924848/ /pubmed/29720851 http://dx.doi.org/10.20524/aog.2018.0239 Text en Copyright: © Hellenic Society of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Review
Tiratterra, Elisa
Franco, Placido
Porru, Emanuele
Katsanos, Konstantinos H.
Christodoulou, Dimitrios K.
Roda, Giulia
Role of bile acids in inflammatory bowel disease
title Role of bile acids in inflammatory bowel disease
title_full Role of bile acids in inflammatory bowel disease
title_fullStr Role of bile acids in inflammatory bowel disease
title_full_unstemmed Role of bile acids in inflammatory bowel disease
title_short Role of bile acids in inflammatory bowel disease
title_sort role of bile acids in inflammatory bowel disease
topic Invited Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924848/
https://www.ncbi.nlm.nih.gov/pubmed/29720851
http://dx.doi.org/10.20524/aog.2018.0239
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