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Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson's Disease

The basal ganglia, which have been shown to be a significant multisensory hub, are disordered in Parkinson's disease (PD). This study was to investigate the audiovisual integration of peripheral stimuli in PD patients with/without sleep disturbances. Thirty-six age-matched normal controls (NC)...

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Autores principales: Ren, Yanna, Suzuki, Keisuke, Yang, Weiping, Ren, Yanling, Wu, Fengxia, Yang, Jiajia, Takahashi, Satoshi, Ejima, Yoshimichi, Wu, Jinglong, Hirata, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924975/
https://www.ncbi.nlm.nih.gov/pubmed/29850014
http://dx.doi.org/10.1155/2018/1648017
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author Ren, Yanna
Suzuki, Keisuke
Yang, Weiping
Ren, Yanling
Wu, Fengxia
Yang, Jiajia
Takahashi, Satoshi
Ejima, Yoshimichi
Wu, Jinglong
Hirata, Koichi
author_facet Ren, Yanna
Suzuki, Keisuke
Yang, Weiping
Ren, Yanling
Wu, Fengxia
Yang, Jiajia
Takahashi, Satoshi
Ejima, Yoshimichi
Wu, Jinglong
Hirata, Koichi
author_sort Ren, Yanna
collection PubMed
description The basal ganglia, which have been shown to be a significant multisensory hub, are disordered in Parkinson's disease (PD). This study was to investigate the audiovisual integration of peripheral stimuli in PD patients with/without sleep disturbances. Thirty-six age-matched normal controls (NC) and 30 PD patients were recruited for an auditory/visual discrimination experiment. The mean response times for each participant were analyzed using repeated measures ANOVA and race model. The results showed that the response to all stimuli was significantly delayed for PD compared to NC (all p < 0.01). The response to audiovisual stimuli was significantly faster than that to unimodal stimuli in both NC and PD (p < 0.001). Additionally, audiovisual integration was absent in PD; however, it did occur in NC. Further analysis showed that there was no significant audiovisual integration in PD with/without cognitive impairment or in PD with/without sleep disturbances. Furthermore, audiovisual facilitation was not associated with Hoehn and Yahr stage, disease duration, or the presence of sleep disturbances (all p > 0.05). The current results showed that audiovisual multisensory integration for peripheral stimuli is absent in PD regardless of sleep disturbances and further suggested the abnormal audiovisual integration might be a potential early manifestation of PD.
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spelling pubmed-59249752018-05-30 Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson's Disease Ren, Yanna Suzuki, Keisuke Yang, Weiping Ren, Yanling Wu, Fengxia Yang, Jiajia Takahashi, Satoshi Ejima, Yoshimichi Wu, Jinglong Hirata, Koichi Parkinsons Dis Research Article The basal ganglia, which have been shown to be a significant multisensory hub, are disordered in Parkinson's disease (PD). This study was to investigate the audiovisual integration of peripheral stimuli in PD patients with/without sleep disturbances. Thirty-six age-matched normal controls (NC) and 30 PD patients were recruited for an auditory/visual discrimination experiment. The mean response times for each participant were analyzed using repeated measures ANOVA and race model. The results showed that the response to all stimuli was significantly delayed for PD compared to NC (all p < 0.01). The response to audiovisual stimuli was significantly faster than that to unimodal stimuli in both NC and PD (p < 0.001). Additionally, audiovisual integration was absent in PD; however, it did occur in NC. Further analysis showed that there was no significant audiovisual integration in PD with/without cognitive impairment or in PD with/without sleep disturbances. Furthermore, audiovisual facilitation was not associated with Hoehn and Yahr stage, disease duration, or the presence of sleep disturbances (all p > 0.05). The current results showed that audiovisual multisensory integration for peripheral stimuli is absent in PD regardless of sleep disturbances and further suggested the abnormal audiovisual integration might be a potential early manifestation of PD. Hindawi 2018-04-12 /pmc/articles/PMC5924975/ /pubmed/29850014 http://dx.doi.org/10.1155/2018/1648017 Text en Copyright © 2018 Yanna Ren et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ren, Yanna
Suzuki, Keisuke
Yang, Weiping
Ren, Yanling
Wu, Fengxia
Yang, Jiajia
Takahashi, Satoshi
Ejima, Yoshimichi
Wu, Jinglong
Hirata, Koichi
Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson's Disease
title Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson's Disease
title_full Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson's Disease
title_fullStr Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson's Disease
title_full_unstemmed Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson's Disease
title_short Absent Audiovisual Integration Elicited by Peripheral Stimuli in Parkinson's Disease
title_sort absent audiovisual integration elicited by peripheral stimuli in parkinson's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924975/
https://www.ncbi.nlm.nih.gov/pubmed/29850014
http://dx.doi.org/10.1155/2018/1648017
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