Cargando…

Epigenetic Modifications of the α-Synuclein Gene and Relative Protein Content Are Affected by Ageing and Physical Exercise in Blood from Healthy Subjects

Epigenetic regulation may contribute to the beneficial effects of physical activity against age-related neurodegeneration. For example, epigenetic alterations of the gene encoding for α-synuclein (SNCA) have been widely explored in both brain and peripheral tissues of Parkinson's disease sample...

Descripción completa

Detalles Bibliográficos
Autores principales:	Daniele, Simona, Costa, Barbara, Pietrobono, Deborah, Giacomelli, Chiara, Iofrida, Caterina, Trincavelli, Maria Letizia, Fusi, Jonathan, Franzoni, Ferdinando, Martini, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924988/ https://www.ncbi.nlm.nih.gov/pubmed/29849887 http://dx.doi.org/10.1155/2018/3740345

Ejemplares similares

α-Synuclein Aggregated with Tau and β-Amyloid in Human Platelets from Healthy Subjects: Correlation with Physical Exercise
por: Daniele, Simona, et al.
Publicado: (2018)

α-Synuclein Heterocomplexes with β-Amyloid Are Increased in Red Blood Cells of Parkinson’s Disease Patients and Correlate with Disease Severity
por: Daniele, Simona, et al.
Publicado: (2018)

Carnosol controls the human glioblastoma stemness features through the epithelial-mesenchymal transition modulation and the induction of cancer stem cell apoptosis
por: Giacomelli, Chiara, et al.
Publicado: (2017)

High Adenosine Extracellular Levels Induce Glioblastoma Aggressive Traits Modulating the Mesenchymal Stromal Cell Secretome
por: Pietrobono, Deborah, et al.
Publicado: (2020)

High Levels of β-Amyloid, Tau, and Phospho-Tau in Red Blood Cells as Biomarkers of Neuropathology in Senescence-Accelerated Mouse
por: Piccarducci, Rebecca, et al.
Publicado: (2019)

Editorial: Physical Activity: Epigenetic and Metabolic Regulation of Brain Aging
por: Daniele, Simona, et al.
Publicado: (2020)

Antioxidant Activity of Compounds Isolated from Elaeagnus umbellata Promotes Human Gingival Fibroblast Well-Being
por: Iannuzzi, Anna Maria, et al.
Publicado: (2020)

Lactate dehydrogenase-A inhibition induces human glioblastoma multiforme stem cell differentiation and death
por: Daniele, Simona, et al.
Publicado: (2015)

Aerobic Exercise and Healthy Nutrition as Neuroprotective Agents for Brain Health in Patients with Parkinson’s Disease: A Critical Review of the Literature
por: Cammisuli, Davide Maria, et al.
Publicado: (2020)

Metabolic and Molecular Mechanisms of Diet and Physical Exercise in the Management of Polycystic Ovarian Syndrome
por: Scarfò, Giorgia, et al.
Publicado: (2022)

The Mediterranean Diet Positively Affects Resting Metabolic Rate and Salivary Microbiota in Human Subjects: A Comparison with the Vegan Regimen
por: Daniele, Simona, et al.
Publicado: (2021)

Apolipoprotein E Polymorphism and Oxidative Stress in Human Peripheral Blood Cells: Can Physical Activity Reactivate the Proteasome System through Epigenetic Mechanisms?
por: Piccarducci, Rebecca, et al.
Publicado: (2021)

Negative effects of a high tumour necrosis factor-α concentration on human gingival mesenchymal stem cell trophism: the use of natural compounds as modulatory agents
por: Giacomelli, Chiara, et al.
Publicado: (2018)

A Rapid and Efficient Immunoenzymatic Assay to Detect Receptor Protein Interactions: G Protein-Coupled Receptors
por: Zappelli, Elisa, et al.
Publicado: (2014)

Unraveling the Complex Interplay between Alpha-Synuclein and Epigenetic Modification
por: Sugeno, Naoto, et al.
Publicado: (2023)

Genes and Aggressive Behavior: Epigenetic Mechanisms Underlying Individual Susceptibility to Aversive Environments
por: Palumbo, Sara, et al.
Publicado: (2018)

Regular exercise delays microvascular endothelial dysfunction by regulating antioxidant capacity and cellular metabolism
por: Scarfò, Giorgia, et al.
Publicado: (2023)

Functional Heterodimerization between the G Protein-Coupled Receptor GPR17 and the Chemokine Receptors 2 and 4: New Evidence
por: Daniele, Simona, et al.
Publicado: (2022)

The A(2B) Adenosine Receptor Modulates the Epithelial– Mesenchymal Transition through the Balance of cAMP/PKA and MAPK/ERK Pathway Activation in Human Epithelial Lung Cells
por: Giacomelli, Chiara, et al.
Publicado: (2018)

Impact of ApoE Polymorphism and Physical Activity on Plasma Antioxidant Capability and Erythrocyte Membranes
por: Piccarducci, Rebecca, et al.
Publicado: (2019)

Allosterism vs. Orthosterism: Recent Findings and Future Perspectives on A(2B) AR Physio-Pathological Implications
por: Barresi, Elisabetta, et al.
Publicado: (2021)

Exploring the Role of Lipid-Binding Proteins and Oxidative Stress in Neurodegenerative Disorders: A Focus on the Neuroprotective Effects of Nutraceutical Supplementation and Physical Exercise
por: Scarfò, Giorgia, et al.
Publicado: (2022)

What Does the Brain Have to Keep Working at Its Best? Resilience Mechanisms Such as Antioxidants and Brain/Cognitive Reserve for Counteracting Alzheimer’s Disease Degeneration
por: Cammisuli, Davide Maria, et al.
Publicado: (2022)

A Minireview Exploring the Interplay of the Muscle-Gut-Brain (MGB) Axis to Improve Knowledge on Mental Disorders: Implications for Clinical Neuroscience Research and Therapeutics
por: Cammisuli, Davide Maria, et al.
Publicado: (2022)

Regulation of Erythropoietin Receptor Activity in Endothelial Cells by Different Erythropoietin (EPO) Derivatives: An in Vitro Study
por: Trincavelli, Maria Letizia, et al.
Publicado: (2013)

Exploring Epithelial–Mesenchymal Transition Signals in Endometriosis Diagnosis and In Vitro Fertilization Outcomes
por: Cela, Vito, et al.
Publicado: (2021)

Antioxidant Capability and Physical Exercise in Neurobiology: A Focus in Neurodegeneration
por: Scarfò, Giorgia, et al.
Publicado: (2021)

Memantine prodrug as a new agent for Alzheimer’s Disease
por: Sestito, Simona, et al.
Publicado: (2019)

Angiogenesis in Disease
por: La Mendola, Diego, et al.
Publicado: (2022)

Paroxysmal Atrial Fibrillation Induced by Ice-Cold Water Ingestion in a Triathlete: A Case Report
por: Scarfò, Giorgia, et al.
Publicado: (2021)

Oxidative Stress-Related Signaling Pathways Predict Oocytes’ Fertilization In Vitro and Embryo Quality
por: Artini, Paolo Giovanni, et al.
Publicado: (2022)

Prodromal Intestinal Events in Alzheimer’s Disease (AD): Colonic Dysmotility and Inflammation Are Associated with Enteric AD-Related Protein Deposition
por: Pellegrini, Carolina, et al.
Publicado: (2020)

α-Synuclein and Mechanisms of Epigenetic Regulation
por: Surguchov, Andrei
Publicado: (2023)

Novel positive allosteric modulators of A(2B) adenosine receptor acting as bone mineralisation promoters
por: Barresi, Elisabetta, et al.
Publicado: (2020)

Apoptosis Therapy in Cancer: The First Single-molecule Co-activating p53 and the Translocator Protein in Glioblastoma
por: Daniele, Simona, et al.
Publicado: (2014)

α-Synuclein Modification in an ALS Animal Model
por: Yang, Eun Jin, et al.
Publicado: (2013)

Development of the first in vivo GPR17 ligand through an iterative drug discovery pipeline: A novel disease-modifying strategy for multiple sclerosis
por: Parravicini, Chiara, et al.
Publicado: (2020)

Modulation of A(1) and A(2B) adenosine receptor activity: a new strategy to sensitise glioblastoma stem cells to chemotherapy
por: Daniele, S, et al.
Publicado: (2014)

Posttranslational Modifications and Clearing of α-Synuclein Aggregates in Yeast
por: Popova, Blagovesta, et al.
Publicado: (2015)

Multimaterial and multiscale scaffold for engineering enthesis organ
por: Micalizzi, Simone, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jse1kfkd09ab93ea1jog80tndi