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DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4(+)CD25(high) FOXP3(+) Regulatory T Cells but Does Not Affect Their Suppressive Capacity

Regulatory T cells (Treg) can show plasticity whereby FOXP3 expression, the master transcription factor for Treg suppressor function, is lost and proinflammatory cytokines are produced. Optimal FOXP3 expression strongly depends on hypomethylation of the FOXP3 gene. 5-Azacytidine (Aza) and its deriva...

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Detalles Bibliográficos
Autores principales:	Landman, Sija, Cruijsen, Marjan, Urbano, Paulo C. M., Huls, Gerwin, van Erp, Piet E. J., van Rijssen, Esther, Joosten, Irma, Koenen, Hans J. P. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924998/ https://www.ncbi.nlm.nih.gov/pubmed/29850630 http://dx.doi.org/10.1155/2018/4973964

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