Cargando…

Methyl Chavicol and Its Synthetic Analogue as Possible Antioxidant and Antilipase Agents Based on the In Vitro and In Silico Assays

This study investigated the in vitro and in silico biological properties of the methyl chavicol (MC) and its analogue 2-[(4-methoxyphenyl)methyl]oxirane (MPMO), emphasizing the antioxidant and antilipase effects. MPMO was synthesized from MC that reacted with meta-chloroperbenzoic acid and, after se...

Descripción completa

Detalles Bibliográficos
Autores principales:	Santos, Bruna Celeida Silva, Pires, Andressa Soares, Yamamoto, Célia Hitomi, Couri, Mara Rubia Costa, Taranto, Alex Gutterres, Alves, Maria Silvana, Araújo, Ana Lúcia dos Santos de Matos, de Sousa, Orlando Vieira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925050/ https://www.ncbi.nlm.nih.gov/pubmed/29849872 http://dx.doi.org/10.1155/2018/2189348

Ejemplares similares

Antiamylase, Antilipase, Antimicrobial, and Cytotoxic Activity of Nonea obtusifolia (Willd.) DC. from Palestine
por: Jaradat, Nidal, et al.
Publicado: (2020)

Vertical Alignment of Liquid Crystals on Comb-Like Renewable Chavicol-Modified Polystyrene
por: Moon, Jihyeon, et al.
Publicado: (2021)

Inhibitory Potential of Synthetic Amino Acid Derivatives against Digestive Enzymes as Promising Hypoglycemic and Anti-Obesity Agents
por: da Silva, Franciane Campos, et al.
Publicado: (2023)

Gamma-tocotrienol and hydroxy-chavicol synergistically inhibits growth and induces apoptosis of human glioma cells
por: Abdul Rahman, Amirah, et al.
Publicado: (2014)

Electrophysiological, behavioural and biochemical effect of Ocimum basilicum oil and its constituents methyl chavicol and linalool on Musca domestica L.
por: Senthoorraja, Rajendran, et al.
Publicado: (2021)

Effect of gibberellic acid (GA), indole acetic acid (IAA) and benzylaminopurine (BAP) on the synthesis of essential oils and the isomerization of methyl chavicol and trans-anethole in Ocimum gratissimum L
por: Hazzoumi, Zakaria, et al.
Publicado: (2014)

Structure-based drug design studies of UDP-N-acetylglucosamine pyrophosphosrylase, a key enzyme for the control of witches’ broom disease
por: Junior, Manoelito C Santos, et al.
Publicado: (2013)

Molecular Multi-Target Approach for Human Acetylcholinesterase, Butyrylcholinesterase and β-Secretase 1: Next Generation for Alzheimer’s Disease Treatment
por: Mendes, Géssica Oliveira, et al.
Publicado: (2023)

Synthetic Analogues of Aminoadamantane as Influenza Viral Inhibitors—In Vitro, In Silico and QSAR Studies
por: Chayrov, Radoslav, et al.
Publicado: (2020)

Structure-Based Virtual Screening: From Classical to Artificial Intelligence
por: Maia, Eduardo Habib Bechelane, et al.
Publicado: (2020)

In vitro and in silico analysis of imatinib analogues as anti-Trypanosoma cruzi drug candidates
por: Nesic de Freitas, Luca S. F., et al.
Publicado: (2023)

Successful application of virtual screening and molecular dynamics simulations against antimalarial molecular targets
por: Nunes, Renata Rachide, et al.
Publicado: (2016)

Structure-based drug design studies of the interactions of ent-kaurane diterpenes derived from Wedelia paludosa with the Plasmodium falciparum sarco/endoplasmic reticulum Ca(2+)-ATPase PfATP6
por: Guimarães, Daniel Silqueira Martins, et al.
Publicado: (2015)

Quinazoline analogues as cytotoxic agents; QSAR, docking, and in silico studies
por: Emami, Leila, et al.
Publicado: (2021)

Synthesis, SAR, and Docking Studies Disclose 2-Arylfuran-1,4-naphthoquinones as In Vitro Antiplasmodial Hits
por: Borgati, Tatiane Freitas, et al.
Publicado: (2017)

Butenafine and analogues: An expeditious synthesis and cytotoxicity and antifungal activities
por: Porras, Ana María Garzón, et al.
Publicado: (2018)

Rational-Based Discovery of Novel β-Carboline Derivatives as Potential Antimalarials: From In Silico Identification of Novel Targets to Inhibition of Experimental Cerebral Malaria
por: Alves, Fernanda de Moura, et al.
Publicado: (2022)

Evaluation of Docking Machine Learning and Molecular Dynamics Methodologies for DNA-Ligand Systems
por: de Oliveira, Tiago Alves, et al.
Publicado: (2022)

Inhibition of IKKβ by celastrol and its analogues – an in silico and in vitro approach
por: Veerappan, Karpagam, et al.
Publicado: (2016)

Brazilian malaria molecular targets (BraMMT): selected receptors for virtual high-throughput screening experiments
por: Nunes, Renata Rachide, et al.
Publicado: (2019)

In silico design and evaluation of novel 5-fluorouracil analogues as potential anticancer agents
por: Chowdhury, Surid Mohammad, et al.
Publicado: (2020)

In silico studies on stilbenolignan analogues as SARS-CoV-2 Mpro inhibitors
por: Cetin, Adnan
Publicado: (2021)

Integrated In Silico Analysis of Pathway Designs for Synthetic Photo-Electro-Autotrophy
por: Volpers, Michael, et al.
Publicado: (2016)

Antinociceptive and Anti-Inflammatory Activities of the Ethanol Extract of Annona muricata L. Leaves in Animal Models
por: de Sousa, Orlando Vieira, et al.
Publicado: (2010)

Synthetic Analogue of Butenolide as an Antifouling Agent
por: Chiang, Ho Yin, et al.
Publicado: (2021)

Synthetic Derivatives against Wild-Type and Non-Wild-Type Sporothrix brasiliensis: In Vitro and In Silico Analyses
por: de Souza, Lais Cavalcanti dos Santos Velasco, et al.
Publicado: (2022)

Inhibition of cytochrome P450 3A by acetoxylated analogues of resveratrol in in vitro and in silico models
por: Basheer, Loai, et al.
Publicado: (2016)

In Silico Screening and In Vitro Activity Measurement of Javamide Analogues as Potential p38 MAPK Inhibitors
por: Park, Jae B.
Publicado: (2017)

In silico Study of the Pharmacologic Properties and Cytotoxicity Pathways in Cancer Cells of Various Indolylquinone Analogues of Perezone
por: Escobedo-González, René, et al.
Publicado: (2017)

In silico designing of a new cysteine analogue of hirudin variant 3 for site specific PEGylation
por: Sajjadi, Seyed Mehdi, et al.
Publicado: (2017)

Design and identification of novel annomontine analogues against SARS-CoV-2: An in-silico approach
por: Waidha, Kamran, et al.
Publicado: (2021)

Apigenin analogues as SARS-CoV-2 main protease inhibitors: In-silico screening approach
por: Farhat, Ameny, et al.
Publicado: (2022)

In silico studies of ASEM analogues targeting α7-nAChR and experimental verification
por: Zhou, Yang, et al.
Publicado: (2021)

In Vitro Cytotoxicity Evaluation of Plastoquinone Analogues against Colorectal and Breast Cancers along with In Silico Insights
por: Ciftci, Halilibrahim, et al.
Publicado: (2022)

The Synthesis, Fungicidal Activity, and in Silico Study of Alkoxy Analogues of Natural Precocenes I, II, and III
por: Ramadan, Khaled M. A., et al.
Publicado: (2022)

Antinociceptive and Anti-Inflammatory Effects of Ethanol Extract from Vernonia polyanthes Leaves in Rodents
por: Temponi, Vanessa dos Santos, et al.
Publicado: (2012)

Combretastatins D series and analogues: from isolation, synthetic challenges and biological activities
por: de Lima Neto, Jorge, et al.
Publicado: (2023)

Insights on variant analysis in silico tools for pathogenicity prediction
por: Garcia, Felipe Antonio de Oliveira, et al.
Publicado: (2022)

Structure–Activity Relationship of Piplartine and Synthetic Analogues against Schistosoma mansoni and Cytotoxicity to Mammalian Cells
por: Campelo, Yuri, et al.
Publicado: (2018)

The In Silico Characterization of a Salicylic Acid Analogue Coding Gene Clusters in Selected Pseudomonas fluorescens Strains
por: Shehroz, Muhammad, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_u1hlh9o55029utc61s7tcrlmis