Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity

We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. These cells can induce lysis of HLA-negative tumor cell lines. The Hsp70 stress molecule on the surface of the tumor cells is u...

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Autores principales: Sharapova, T. N., Romanova, E. A., Sashchenko, L. P., Yashin, D. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925135/
https://www.ncbi.nlm.nih.gov/pubmed/29850628
http://dx.doi.org/10.1155/2018/4501273
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author Sharapova, T. N.
Romanova, E. A.
Sashchenko, L. P.
Yashin, D. V.
author_facet Sharapova, T. N.
Romanova, E. A.
Sashchenko, L. P.
Yashin, D. V.
author_sort Sharapova, T. N.
collection PubMed
description We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. These cells can induce lysis of HLA-negative tumor cell lines. The Hsp70 stress molecule on the surface of the tumor cells is used as a recognition target, while the Tag7 protein on the lymphocyte membrane acts as a receptor for Hsp70. We have also demonstrated that this subpopulation of the CD4+CD25+ cells is CD127 positive and hence is not the Treg cells. Our data suggest that this subpopulation of cells is identical to the CD4+CD25+ lymphocytes, which are activated in the leukocyte pool by the IL-2 cytokine.
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spelling pubmed-59251352018-05-30 Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity Sharapova, T. N. Romanova, E. A. Sashchenko, L. P. Yashin, D. V. J Immunol Res Research Article We have shown that in the human peripheral blood cells, the innate immunity protein Tag7 can activate a subpopulation of CD3+CD4+CD25+ cells, which have antitumor activity. These cells can induce lysis of HLA-negative tumor cell lines. The Hsp70 stress molecule on the surface of the tumor cells is used as a recognition target, while the Tag7 protein on the lymphocyte membrane acts as a receptor for Hsp70. We have also demonstrated that this subpopulation of the CD4+CD25+ cells is CD127 positive and hence is not the Treg cells. Our data suggest that this subpopulation of cells is identical to the CD4+CD25+ lymphocytes, which are activated in the leukocyte pool by the IL-2 cytokine. Hindawi 2018-04-11 /pmc/articles/PMC5925135/ /pubmed/29850628 http://dx.doi.org/10.1155/2018/4501273 Text en Copyright © 2018 T. N. Sharapova et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sharapova, T. N.
Romanova, E. A.
Sashchenko, L. P.
Yashin, D. V.
Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity
title Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity
title_full Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity
title_fullStr Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity
title_full_unstemmed Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity
title_short Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity
title_sort tag7 (pglyrp1) can induce an emergence of the cd3+cd4+cd25+cd127+ cells with antitumor activity
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925135/
https://www.ncbi.nlm.nih.gov/pubmed/29850628
http://dx.doi.org/10.1155/2018/4501273
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