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Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer
INTRODUCTION: The aim of the study was to compare serum concentration of soluble L- and P-selectins in women with ovarian cancer (OC) and healthy controls, and to investigate sL- and sP-selectin levels with regard to clinical and pathological parameters. Correlation analysis was used to measure the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925195/ https://www.ncbi.nlm.nih.gov/pubmed/29725279 http://dx.doi.org/10.5114/pm.2018.74897 |
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author | Majchrzak-Baczmańska, Dominika B. Głowacka, Ewa Wilczyński, Miłosz Malinowski, Andrzej |
author_facet | Majchrzak-Baczmańska, Dominika B. Głowacka, Ewa Wilczyński, Miłosz Malinowski, Andrzej |
author_sort | Majchrzak-Baczmańska, Dominika B. |
collection | PubMed |
description | INTRODUCTION: The aim of the study was to compare serum concentration of soluble L- and P-selectins in women with ovarian cancer (OC) and healthy controls, and to investigate sL- and sP-selectin levels with regard to clinical and pathological parameters. Correlation analysis was used to measure the following: sL- and sP-selectin concentration and Ca125; sP-selectin and platelet concentrations; and sL-selectin and serum leukocyte levels in women with OC. MATERIAL AND METHODS: The study included 29 patients with OC and 23 healthy controls. Serum concentrations of sL- and sP-selectins were measured in all subjects. Routine diagnostic tests: CBC and USG (both groups) and Ca125 (study group) were performed. RESULTS: Significantly higher serum concentrations of sL- and sP-selectins were found in the study group as compared to controls. Lower levels of serum sL-selectin were observed in women with poorly-differentiated OC (G3) and advanced stages of the disease (FIGO III, IV), but the results were statistically insignificant. No statistically significant relationship was detected between sP-selectin serum concentration in women with OC and tumour differentiation, histological type, and stage of the disease. No significant correlation was found between sL- and sP-selectins and Ca125 levels. A weak correlation was found between serum concentration of sP-selectin in women with OC and platelet count. No statistically significant correlation was observed between sL-selectin concentration and serum leukocyte levels in women with OC. CONCLUSIONS: The analysis of sL- and sP-selectin concentrations may be a useful tool in the diagnosis of OC. The levels of sL-selectin decrease with disease progression. |
format | Online Article Text |
id | pubmed-5925195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-59251952018-05-03 Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer Majchrzak-Baczmańska, Dominika B. Głowacka, Ewa Wilczyński, Miłosz Malinowski, Andrzej Prz Menopauzalny Original Paper INTRODUCTION: The aim of the study was to compare serum concentration of soluble L- and P-selectins in women with ovarian cancer (OC) and healthy controls, and to investigate sL- and sP-selectin levels with regard to clinical and pathological parameters. Correlation analysis was used to measure the following: sL- and sP-selectin concentration and Ca125; sP-selectin and platelet concentrations; and sL-selectin and serum leukocyte levels in women with OC. MATERIAL AND METHODS: The study included 29 patients with OC and 23 healthy controls. Serum concentrations of sL- and sP-selectins were measured in all subjects. Routine diagnostic tests: CBC and USG (both groups) and Ca125 (study group) were performed. RESULTS: Significantly higher serum concentrations of sL- and sP-selectins were found in the study group as compared to controls. Lower levels of serum sL-selectin were observed in women with poorly-differentiated OC (G3) and advanced stages of the disease (FIGO III, IV), but the results were statistically insignificant. No statistically significant relationship was detected between sP-selectin serum concentration in women with OC and tumour differentiation, histological type, and stage of the disease. No significant correlation was found between sL- and sP-selectins and Ca125 levels. A weak correlation was found between serum concentration of sP-selectin in women with OC and platelet count. No statistically significant correlation was observed between sL-selectin concentration and serum leukocyte levels in women with OC. CONCLUSIONS: The analysis of sL- and sP-selectin concentrations may be a useful tool in the diagnosis of OC. The levels of sL-selectin decrease with disease progression. Termedia Publishing House 2018-04-11 2018-03 /pmc/articles/PMC5925195/ /pubmed/29725279 http://dx.doi.org/10.5114/pm.2018.74897 Text en Copyright: © 2018 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Original Paper Majchrzak-Baczmańska, Dominika B. Głowacka, Ewa Wilczyński, Miłosz Malinowski, Andrzej Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer |
title | Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer |
title_full | Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer |
title_fullStr | Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer |
title_full_unstemmed | Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer |
title_short | Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer |
title_sort | serum concentrations of soluble (s)l- and (s)p-selectins in women with ovarian cancer |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925195/ https://www.ncbi.nlm.nih.gov/pubmed/29725279 http://dx.doi.org/10.5114/pm.2018.74897 |
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