Cargando…

Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer

INTRODUCTION: The aim of the study was to compare serum concentration of soluble L- and P-selectins in women with ovarian cancer (OC) and healthy controls, and to investigate sL- and sP-selectin levels with regard to clinical and pathological parameters. Correlation analysis was used to measure the...

Descripción completa

Detalles Bibliográficos
Autores principales: Majchrzak-Baczmańska, Dominika B., Głowacka, Ewa, Wilczyński, Miłosz, Malinowski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925195/
https://www.ncbi.nlm.nih.gov/pubmed/29725279
http://dx.doi.org/10.5114/pm.2018.74897
_version_ 1783318668420055040
author Majchrzak-Baczmańska, Dominika B.
Głowacka, Ewa
Wilczyński, Miłosz
Malinowski, Andrzej
author_facet Majchrzak-Baczmańska, Dominika B.
Głowacka, Ewa
Wilczyński, Miłosz
Malinowski, Andrzej
author_sort Majchrzak-Baczmańska, Dominika B.
collection PubMed
description INTRODUCTION: The aim of the study was to compare serum concentration of soluble L- and P-selectins in women with ovarian cancer (OC) and healthy controls, and to investigate sL- and sP-selectin levels with regard to clinical and pathological parameters. Correlation analysis was used to measure the following: sL- and sP-selectin concentration and Ca125; sP-selectin and platelet concentrations; and sL-selectin and serum leukocyte levels in women with OC. MATERIAL AND METHODS: The study included 29 patients with OC and 23 healthy controls. Serum concentrations of sL- and sP-selectins were measured in all subjects. Routine diagnostic tests: CBC and USG (both groups) and Ca125 (study group) were performed. RESULTS: Significantly higher serum concentrations of sL- and sP-selectins were found in the study group as compared to controls. Lower levels of serum sL-selectin were observed in women with poorly-differentiated OC (G3) and advanced stages of the disease (FIGO III, IV), but the results were statistically insignificant. No statistically significant relationship was detected between sP-selectin serum concentration in women with OC and tumour differentiation, histological type, and stage of the disease. No significant correlation was found between sL- and sP-selectins and Ca125 levels. A weak correlation was found between serum concentration of sP-selectin in women with OC and platelet count. No statistically significant correlation was observed between sL-selectin concentration and serum leukocyte levels in women with OC. CONCLUSIONS: The analysis of sL- and sP-selectin concentrations may be a useful tool in the diagnosis of OC. The levels of sL-selectin decrease with disease progression.
format Online
Article
Text
id pubmed-5925195
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Termedia Publishing House
record_format MEDLINE/PubMed
spelling pubmed-59251952018-05-03 Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer Majchrzak-Baczmańska, Dominika B. Głowacka, Ewa Wilczyński, Miłosz Malinowski, Andrzej Prz Menopauzalny Original Paper INTRODUCTION: The aim of the study was to compare serum concentration of soluble L- and P-selectins in women with ovarian cancer (OC) and healthy controls, and to investigate sL- and sP-selectin levels with regard to clinical and pathological parameters. Correlation analysis was used to measure the following: sL- and sP-selectin concentration and Ca125; sP-selectin and platelet concentrations; and sL-selectin and serum leukocyte levels in women with OC. MATERIAL AND METHODS: The study included 29 patients with OC and 23 healthy controls. Serum concentrations of sL- and sP-selectins were measured in all subjects. Routine diagnostic tests: CBC and USG (both groups) and Ca125 (study group) were performed. RESULTS: Significantly higher serum concentrations of sL- and sP-selectins were found in the study group as compared to controls. Lower levels of serum sL-selectin were observed in women with poorly-differentiated OC (G3) and advanced stages of the disease (FIGO III, IV), but the results were statistically insignificant. No statistically significant relationship was detected between sP-selectin serum concentration in women with OC and tumour differentiation, histological type, and stage of the disease. No significant correlation was found between sL- and sP-selectins and Ca125 levels. A weak correlation was found between serum concentration of sP-selectin in women with OC and platelet count. No statistically significant correlation was observed between sL-selectin concentration and serum leukocyte levels in women with OC. CONCLUSIONS: The analysis of sL- and sP-selectin concentrations may be a useful tool in the diagnosis of OC. The levels of sL-selectin decrease with disease progression. Termedia Publishing House 2018-04-11 2018-03 /pmc/articles/PMC5925195/ /pubmed/29725279 http://dx.doi.org/10.5114/pm.2018.74897 Text en Copyright: © 2018 Termedia Sp. z o. o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Majchrzak-Baczmańska, Dominika B.
Głowacka, Ewa
Wilczyński, Miłosz
Malinowski, Andrzej
Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer
title Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer
title_full Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer
title_fullStr Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer
title_full_unstemmed Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer
title_short Serum concentrations of soluble (s)L- and (s)P-selectins in women with ovarian cancer
title_sort serum concentrations of soluble (s)l- and (s)p-selectins in women with ovarian cancer
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925195/
https://www.ncbi.nlm.nih.gov/pubmed/29725279
http://dx.doi.org/10.5114/pm.2018.74897
work_keys_str_mv AT majchrzakbaczmanskadominikab serumconcentrationsofsolubleslandspselectinsinwomenwithovariancancer
AT głowackaewa serumconcentrationsofsolubleslandspselectinsinwomenwithovariancancer
AT wilczynskimiłosz serumconcentrationsofsolubleslandspselectinsinwomenwithovariancancer
AT malinowskiandrzej serumconcentrationsofsolubleslandspselectinsinwomenwithovariancancer