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A Single Codon Optimization Enhances Recombinant Human TNF-α Vaccine Expression in Escherichia coli

As a proinflammatory cytokine, tumor necrosis factor-alpha (TNF-α) plays a pivotal role in various autoimmune diseases such as rheumatoid arthritis (RA). Thus, TNF-α has been defined as a therapeutic target for RA. Although some TNF-α antagonists including neutralizing monoclonal antibodies and solu...

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Detalles Bibliográficos
Autores principales:	Chu, Chu, Zhang, Wangqian, Li, Jialin, Wan, Yi, Wang, Zenglu, Duan, Ruyi, Yu, Pei, Zhao, Ning, Zhang, Kuo, Wang, Shuning, Hao, Qiang, Li, Weina, Zhang, Cun, Zhang, Wei, Zhang, Yingqi, Li, Meng, Xue, Xiaochang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925214/ https://www.ncbi.nlm.nih.gov/pubmed/29850502 http://dx.doi.org/10.1155/2018/3025169

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