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The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults
High‐intensity intermittent training (HIIT) has been shown to reduce the risk of chronic conditions including the development of type 2 diabetes mellitus (T2DM). Independently, a low vitamin D status has also been linked to the prevalence of T2DM. The aim of this study was to investigate if there wa...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925425/ https://www.ncbi.nlm.nih.gov/pubmed/29707918 http://dx.doi.org/10.14814/phy2.13684 |
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author | Lithgow, Hannah Margaret Florida‐James, Geraint Leggate, Melanie |
author_facet | Lithgow, Hannah Margaret Florida‐James, Geraint Leggate, Melanie |
author_sort | Lithgow, Hannah Margaret |
collection | PubMed |
description | High‐intensity intermittent training (HIIT) has been shown to reduce the risk of chronic conditions including the development of type 2 diabetes mellitus (T2DM). Independently, a low vitamin D status has also been linked to the prevalence of T2DM. The aim of this study was to investigate if there was a synergistic metabolic effect of HIIT and vitamin D supplementation on glycemic control. A total of 20 male and female participants (age, 34 ± 9 year; BMI, 31.4 ± 2.8 kg·m(−2)) completed 6 weeks HIIT, and were randomized to ingest 100 μg·day(‐1) of vitamin D(3) or placebo. Response to an oral glucose tolerance test (OGTT) was determined at baseline and at 72 h postintervention. Glucose tolerance was improved as a result of the HIIT intervention, shown through a reduction in glucose and insulin concentrations during the OGTT, accompanied by a decrease in glucose (829 ± 110 to 786 ± 139 mmol·h(−1)·L(−1); P = 0.043) and insulin (8101 ± 4755–7024 ± 4489 mU·h(−1)·L(−1); P = 0.049) area under the curve (AUC). Supplementation increased 25‐hydroxyvitamin D(3) concentration by 120% to a sufficiency status (P < 0.001). However, the consumption of vitamin D(3) seemed to attenuate the glucose response during an OGTT. Triglyceride content was lowered following the intervention (P = 0.025). There was no effect of the intervention on insulin sensitivity (IS) indices: ISI(M) (atsuda) and HOMA‐IR. Our findings demonstrate that HIIT improves glucose tolerance in nondiabetic overweight and obese adults; however vitamin D(3) supplementation did not proffer any additional positive effects on the measured indices of metabolic health. |
format | Online Article Text |
id | pubmed-5925425 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59254252018-05-07 The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults Lithgow, Hannah Margaret Florida‐James, Geraint Leggate, Melanie Physiol Rep Original Research High‐intensity intermittent training (HIIT) has been shown to reduce the risk of chronic conditions including the development of type 2 diabetes mellitus (T2DM). Independently, a low vitamin D status has also been linked to the prevalence of T2DM. The aim of this study was to investigate if there was a synergistic metabolic effect of HIIT and vitamin D supplementation on glycemic control. A total of 20 male and female participants (age, 34 ± 9 year; BMI, 31.4 ± 2.8 kg·m(−2)) completed 6 weeks HIIT, and were randomized to ingest 100 μg·day(‐1) of vitamin D(3) or placebo. Response to an oral glucose tolerance test (OGTT) was determined at baseline and at 72 h postintervention. Glucose tolerance was improved as a result of the HIIT intervention, shown through a reduction in glucose and insulin concentrations during the OGTT, accompanied by a decrease in glucose (829 ± 110 to 786 ± 139 mmol·h(−1)·L(−1); P = 0.043) and insulin (8101 ± 4755–7024 ± 4489 mU·h(−1)·L(−1); P = 0.049) area under the curve (AUC). Supplementation increased 25‐hydroxyvitamin D(3) concentration by 120% to a sufficiency status (P < 0.001). However, the consumption of vitamin D(3) seemed to attenuate the glucose response during an OGTT. Triglyceride content was lowered following the intervention (P = 0.025). There was no effect of the intervention on insulin sensitivity (IS) indices: ISI(M) (atsuda) and HOMA‐IR. Our findings demonstrate that HIIT improves glucose tolerance in nondiabetic overweight and obese adults; however vitamin D(3) supplementation did not proffer any additional positive effects on the measured indices of metabolic health. John Wiley and Sons Inc. 2018-04-30 /pmc/articles/PMC5925425/ /pubmed/29707918 http://dx.doi.org/10.14814/phy2.13684 Text en © 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Lithgow, Hannah Margaret Florida‐James, Geraint Leggate, Melanie The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults |
title | The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults |
title_full | The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults |
title_fullStr | The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults |
title_full_unstemmed | The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults |
title_short | The combined effect of high‐intensity intermittent training and vitamin D supplementation on glycemic control in overweight and obese adults |
title_sort | combined effect of high‐intensity intermittent training and vitamin d supplementation on glycemic control in overweight and obese adults |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925425/ https://www.ncbi.nlm.nih.gov/pubmed/29707918 http://dx.doi.org/10.14814/phy2.13684 |
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