Comparisons of Superiority, Non-inferiority, and Equivalence Trials

Efficacy of a new drug or treatment is usually established through randomized clinical trials. However, specifying hypotheses remains a challenging problem for biomedical researchers. In this survey we discuss superiority, non-inferiority, and equivalence trials. These three types of trials have dif...

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Detalles Bibliográficos
Autores principales: WANG, Bokai, WANG, Hongyue, TU, Xin M., FENG, Changyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shanghai Municipal Bureau of Publishing 2017
Materias:
Biostatistics in Psychiatry (42)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925592/
https://www.ncbi.nlm.nih.gov/pubmed/29719352
http://dx.doi.org/10.11919/j.issn.1002-0829.217163
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author WANG, Bokai
WANG, Hongyue
TU, Xin M.
FENG, Changyong
author_facet WANG, Bokai
WANG, Hongyue
TU, Xin M.
FENG, Changyong
author_sort WANG, Bokai
collection PubMed
description Efficacy of a new drug or treatment is usually established through randomized clinical trials. However, specifying hypotheses remains a challenging problem for biomedical researchers. In this survey we discuss superiority, non-inferiority, and equivalence trials. These three types of trials have different assumptions on treatment effects. We compare the assumptions underlying these trials and provide sample size formulas.
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spelling pubmed-59255922018-05-01 Comparisons of Superiority, Non-inferiority, and Equivalence Trials WANG, Bokai WANG, Hongyue TU, Xin M. FENG, Changyong Shanghai Arch Psychiatry Biostatistics in Psychiatry (42) Efficacy of a new drug or treatment is usually established through randomized clinical trials. However, specifying hypotheses remains a challenging problem for biomedical researchers. In this survey we discuss superiority, non-inferiority, and equivalence trials. These three types of trials have different assumptions on treatment effects. We compare the assumptions underlying these trials and provide sample size formulas. Shanghai Municipal Bureau of Publishing 2017-12-25 2017-12-25 /pmc/articles/PMC5925592/ /pubmed/29719352 http://dx.doi.org/10.11919/j.issn.1002-0829.217163 Text en © Shanghai Municipal Bureau of Publishing http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Biostatistics in Psychiatry (42)
WANG, Bokai
WANG, Hongyue
TU, Xin M.
FENG, Changyong
Comparisons of Superiority, Non-inferiority, and Equivalence Trials
title Comparisons of Superiority, Non-inferiority, and Equivalence Trials
title_full Comparisons of Superiority, Non-inferiority, and Equivalence Trials
title_fullStr Comparisons of Superiority, Non-inferiority, and Equivalence Trials
title_full_unstemmed Comparisons of Superiority, Non-inferiority, and Equivalence Trials
title_short Comparisons of Superiority, Non-inferiority, and Equivalence Trials
title_sort comparisons of superiority, non-inferiority, and equivalence trials
topic Biostatistics in Psychiatry (42)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925592/
https://www.ncbi.nlm.nih.gov/pubmed/29719352
http://dx.doi.org/10.11919/j.issn.1002-0829.217163
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