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The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng

BACKGROUND: Compound K (CK) is a ginsenoside, a metabolite of Panax ginseng. There is interest both in increasing skin health and antiaging using natural skin care products. In this study, we explored the possibility of using CK as a cosmetic ingredient. METHODS: To assess the antiaging effect of CK...

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Autores principales: Kim, Eunji, Kim, Donghyun, Yoo, Sulgi, Hong, Yo Han, Han, Sang Yun, Jeong, Seonggu, Jeong, Deok, Kim, Jong-Hoon, Cho, Jae Youl, Park, Junseong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925615/
https://www.ncbi.nlm.nih.gov/pubmed/29719469
http://dx.doi.org/10.1016/j.jgr.2017.03.007
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author Kim, Eunji
Kim, Donghyun
Yoo, Sulgi
Hong, Yo Han
Han, Sang Yun
Jeong, Seonggu
Jeong, Deok
Kim, Jong-Hoon
Cho, Jae Youl
Park, Junseong
author_facet Kim, Eunji
Kim, Donghyun
Yoo, Sulgi
Hong, Yo Han
Han, Sang Yun
Jeong, Seonggu
Jeong, Deok
Kim, Jong-Hoon
Cho, Jae Youl
Park, Junseong
author_sort Kim, Eunji
collection PubMed
description BACKGROUND: Compound K (CK) is a ginsenoside, a metabolite of Panax ginseng. There is interest both in increasing skin health and antiaging using natural skin care products. In this study, we explored the possibility of using CK as a cosmetic ingredient. METHODS: To assess the antiaging effect of CK, RT-PCR was performed, and expression levels of matrix metalloproteinase-1, cyclooxygenase-2, and type I collagen were measured under UVB irradiation conditions. The skin hydrating effect of CK was tested by RT-PCR, and its regulation was explored through immunoblotting. Melanin content, melanin secretion, and tyrosinase activity assays were performed. RESULTS: CK treatment reduced the production of matrix metalloproteinase-1 and cyclooxygenase-2 in UVB irradiated NIH3T3 cells and recovered type I collagen expression level. Expression of skin hydrating factors—filaggrin, transglutaminase, and hyaluronic acid synthases-1 and -2—were augmented by CK and were modulated through the inhibitor of κBα, c-Jun N-terminal kinase, or extracellular signal-regulated kinases pathway. In the melanogenic response, CK did not regulate tyrosinase activity and melanin secretion, but increased melanin content in B16F10 cells was observed. CONCLUSION: Our data showed that CK has antiaging and hydrating effects. We suggest that CK could be used in cosmetic products to protect the skin from UVB rays and increase skin moisture level.
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spelling pubmed-59256152018-05-01 The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng Kim, Eunji Kim, Donghyun Yoo, Sulgi Hong, Yo Han Han, Sang Yun Jeong, Seonggu Jeong, Deok Kim, Jong-Hoon Cho, Jae Youl Park, Junseong J Ginseng Res Research Article BACKGROUND: Compound K (CK) is a ginsenoside, a metabolite of Panax ginseng. There is interest both in increasing skin health and antiaging using natural skin care products. In this study, we explored the possibility of using CK as a cosmetic ingredient. METHODS: To assess the antiaging effect of CK, RT-PCR was performed, and expression levels of matrix metalloproteinase-1, cyclooxygenase-2, and type I collagen were measured under UVB irradiation conditions. The skin hydrating effect of CK was tested by RT-PCR, and its regulation was explored through immunoblotting. Melanin content, melanin secretion, and tyrosinase activity assays were performed. RESULTS: CK treatment reduced the production of matrix metalloproteinase-1 and cyclooxygenase-2 in UVB irradiated NIH3T3 cells and recovered type I collagen expression level. Expression of skin hydrating factors—filaggrin, transglutaminase, and hyaluronic acid synthases-1 and -2—were augmented by CK and were modulated through the inhibitor of κBα, c-Jun N-terminal kinase, or extracellular signal-regulated kinases pathway. In the melanogenic response, CK did not regulate tyrosinase activity and melanin secretion, but increased melanin content in B16F10 cells was observed. CONCLUSION: Our data showed that CK has antiaging and hydrating effects. We suggest that CK could be used in cosmetic products to protect the skin from UVB rays and increase skin moisture level. Elsevier 2018-04 2017-03-25 /pmc/articles/PMC5925615/ /pubmed/29719469 http://dx.doi.org/10.1016/j.jgr.2017.03.007 Text en © 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Kim, Eunji
Kim, Donghyun
Yoo, Sulgi
Hong, Yo Han
Han, Sang Yun
Jeong, Seonggu
Jeong, Deok
Kim, Jong-Hoon
Cho, Jae Youl
Park, Junseong
The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng
title The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng
title_full The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng
title_fullStr The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng
title_full_unstemmed The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng
title_short The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from Panax ginseng
title_sort skin protective effects of compound k, a metabolite of ginsenoside rb1 from panax ginseng
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925615/
https://www.ncbi.nlm.nih.gov/pubmed/29719469
http://dx.doi.org/10.1016/j.jgr.2017.03.007
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