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Impact of altered phosphorylation on loss of function of juvenile Parkinsonism–associated genetic variants of the E3 ligase parkin

Autosomal recessive juvenile Parkinsonism (ARJP) is an inherited neurodegenerative disease in which 50% of affected individuals harbor mutations in the gene encoding the E3 ligase parkin. Parkin regulates the mitochondrial recycling pathway, which is induced by oxidative stress. In its native state,...

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Detalles Bibliográficos
Autores principales:	Aguirre, Jacob D., Dunkerley, Karen M., Lam, Rica, Rusal, Michele, Shaw, Gary S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925814/ https://www.ncbi.nlm.nih.gov/pubmed/29530980 http://dx.doi.org/10.1074/jbc.RA117.000605

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