Cargando…

Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054

BACKGROUND: Modulation of the PD-1/PD-L1 axis through antagonist antibodies that block either receptor or ligand has been shown to reinvigorate the function of tumor-specific T cells and unleash potent anti-tumor immunity, leading to durable objective responses in a subset of patients across multipl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yiwen, Carpenito, Carmine, Wang, George, Surguladze, David, Forest, Amelie, Malabunga, Maria, Murphy, Mary, Zhang, Yiwei, Sonyi, Andreas, Chin, Darin, Burtrum, Douglas, Inigo, Ivan, Pennello, Anthony, Shen, Leyi, Malherbe, Laurent, Chen, Xinlei, Hall, Gerald, Haidar, Jaafar N., Ludwig, Dale L., Novosiadly, Ruslan D., Kalos, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925824/ https://www.ncbi.nlm.nih.gov/pubmed/29712568 http://dx.doi.org/10.1186/s40425-018-0329-7

Ejemplares similares

Correction to: Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054
por: Li, Yiwen, et al.
Publicado: (2018)

High-content molecular profiling of T-cell therapy in oncology
por: Novosiadly, Ruslan, et al.
Publicado: (2016)

Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade
por: Holmgaard, Rikke B., et al.
Publicado: (2018)

Targeting the TGFβ pathway with galunisertib, a TGFβRI SMI, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint inhibition
por: Schaer, David, et al.
Publicado: (2015)

A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation
por: Shen, Yang, et al.
Publicado: (2015)

Treatment with a VEGFR-2 antibody results in intra-tumor immune modulation and enhances anti-tumor efficacy of PD-L1 blockade in syngeneic murine tumor models
por: Li, Yanxia, et al.
Publicado: (2022)

Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome
por: Luo, Linlin, et al.
Publicado: (2016)

Developmental and communicative interrelations of Ly123 and Ly1 cell sets
Publicado: (1980)

Neces-SARI-ly?
por: Martin-Loeches, Ignacio, et al.
Publicado: (2016)

Running Mad-ly into mitosis
por: LeBrasseur, Nicole
Publicado: (2004)

Virulence profile: Hinh Ly
por: Ly, Hinh
Publicado: (2016)

Comparison of Mouse Ly5(a) and Ly5(b) Leucocyte Common Antigen Alleles
por: Zebedee, Suzanne L., et al.
Publicado: (1991)

Secretion of Ia antigens by a subpopulation of T cells which are Ly-1+, Ly-2-, and Ia-
Publicado: (1976)

Expression of Ly 1, Ly 2, Thy 1, and TL differentiation antigens on mouse T-cell tumors
Publicado: (1978)

Occurrences and Functions of Ly6C(hi) and Ly6C(lo) Macrophages in Health and Disease
por: Li, Yuan-hui, et al.
Publicado: (2022)

Models of Ly$\alpha$ forest clouds
por: Charlton, J C
Publicado: (1995)

Role of Ly-6 in lymphocyte activation. II. Induction of T cell activation by monoclonal anti-Ly-6 antibodies
Publicado: (1986)

Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455
por: Wu, Daichao, et al.
Publicado: (2016)

Splenic Ly6G(high) mature and Ly6G(int) immature neutrophils contribute to eradication of S. pneumoniae
por: Deniset, Justin F., et al.
Publicado: (2017)

MSCs Contribute to the Conversion of Ly6C(high) Monocytes into Ly6C(low) Subsets under AMI
por: Lu, Wenbin, et al.
Publicado: (2020)

LncRNA lncLy6C induced by microbiota metabolite butyrate promotes differentiation of Ly6C(high) to Ly6C(int/neg) macrophages through lncLy6C/C/EBPβ/Nr4A1 axis
por: Gao, Yunhuan, et al.
Publicado: (2020)

Ly phenotype of cytotoxic T cells for syngeneic tumor
Publicado: (1976)

Cell size control is sirtuin(ly) exciting
por: Wright, Jill, et al.
Publicado: (2013)

Independent differentiative pathways of Ly1 and Ly23 subclasses of T cells. Experimental production of mice deprived of selected T-cell subclasses
Publicado: (1976)

Mechanisms of Ly2 suppressor cell activity. Activation of an Ly1 I-J+ cell is required to transduce the suppressive signal
Publicado: (1984)

Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity
Publicado: (1975)

Distinct mobilization of leukocytes and hematopoietic stem cells by CXCR4 peptide antagonist LY2510924 and monoclonal antibody LY2624587
por: Peng, Sheng-Bin, et al.
Publicado: (2017)

Varespladib (LY315920) and Methyl Varespladib (LY333013) Abrogate or Delay Lethality Induced by Presynaptically Acting Neurotoxic Snake Venoms
por: Gutiérrez, José María, et al.
Publicado: (2020)

Conversion of Normal Ly-1-Positive B-Lineage Cells into Ly-1-Positive Macrophages in Long-Term Bone Marrow Cultures
por: Katoh, Shigeki, et al.
Publicado: (1990)

Ly6C(-) Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C(+) Monocytes into Macrophages
por: Morias, Yannick, et al.
Publicado: (2015)

Ly6C(low) and Not Ly6C(high) Macrophages Accumulate First in the Heart in a Model of Murine Pressure-Overload
por: Weisheit, Christina, et al.
Publicado: (2014)

CCR2 Deficiency Impairs Ly6C(lo) and Ly6C(hi) Monocyte Responses in Orientia tsutsugamushi Infection
por: Petermann, Michael, et al.
Publicado: (2021)

Removal of a C-terminal serine residue proximal to the inter-chain disulfide bond of a human IgG1 lambda light chain mediates enhanced antibody stability and antibody dependent cell-mediated cytotoxicity
por: Shen, Yang, et al.
Publicado: (2013)

Tolerance for self IG at the level of the Ly1+ T cell
Publicado: (1983)

Probing Ly$\alpha$ absorbers with double lines of sight
por: Charlton, J C, et al.
Publicado: (1995)

Gravitational lensing of QSOs by their damped Ly$\alpha$ absorbers
por: Bartelmann, M, et al.
Publicado: (1995)

Ly49 Receptors: Innate and Adaptive Immune Paradigms
por: Rahim, Mir Munir A., et al.
Publicado: (2014)

Radiosensitization by the Selective Pan-FGFR Inhibitor LY2874455
por: Darwis, Narisa Dewi Maulany, et al.
Publicado: (2022)

Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2)
Publicado: (1995)

CD11b(+)Ly6C(++)Ly6G(-) cells show distinct function in mice with chronic inflammation or tumor burden
por: Källberg, Eva, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_d9j7po3en0h2v4g211g0h5rngn