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Enhanced Sonodynamic Antitumor Effect of Ultrasound in the Presence of Nonsteroidal Anti‐inflammatory Drugs

The antitumor effects of non‐steroidal anti‐inflammatory drugs, tenoxicam and piroxicam, against sarcoma 180 cells cultured in 7‐week‐old male mice were examined in vitro under ultrasonic irradiation. The survival rate of tumor cells when tenoxicam or piroxicam was added to sarcoma 180 suspension un...

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Detalles Bibliográficos
Autores principales: Sakusabe, Noboru, Okada, Kyoji, Sato, Kozo, Kamada, Shinko, Yoshida, Yasuo, Suzuki, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925999/
https://www.ncbi.nlm.nih.gov/pubmed/10595744
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00689.x
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author Sakusabe, Noboru
Okada, Kyoji
Sato, Kozo
Kamada, Shinko
Yoshida, Yasuo
Suzuki, Toshio
author_facet Sakusabe, Noboru
Okada, Kyoji
Sato, Kozo
Kamada, Shinko
Yoshida, Yasuo
Suzuki, Toshio
author_sort Sakusabe, Noboru
collection PubMed
description The antitumor effects of non‐steroidal anti‐inflammatory drugs, tenoxicam and piroxicam, against sarcoma 180 cells cultured in 7‐week‐old male mice were examined in vitro under ultrasonic irradiation. The survival rate of tumor cells when tenoxicam or piroxicam was added to sarcoma 180 suspension under ultrasonic irradiation was significantly lower than that when ultrasound alone was applied. Furthermore, when L‐histidine, a scavenger of singlet oxygen and hydroxyl radical, or D‐mannitol, a scavenger of hydroxyl radical, was used concurrently, the survival rate of tumor cells was significantly higher with L‐histidine. From the above findings, it is surmised that tenoxicam and piroxicam increase the antitumor effects of ultrasound by increasing the production of singlet oxygen and other active oxygen species.
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spelling pubmed-59259992018-05-11 Enhanced Sonodynamic Antitumor Effect of Ultrasound in the Presence of Nonsteroidal Anti‐inflammatory Drugs Sakusabe, Noboru Okada, Kyoji Sato, Kozo Kamada, Shinko Yoshida, Yasuo Suzuki, Toshio Jpn J Cancer Res Article The antitumor effects of non‐steroidal anti‐inflammatory drugs, tenoxicam and piroxicam, against sarcoma 180 cells cultured in 7‐week‐old male mice were examined in vitro under ultrasonic irradiation. The survival rate of tumor cells when tenoxicam or piroxicam was added to sarcoma 180 suspension under ultrasonic irradiation was significantly lower than that when ultrasound alone was applied. Furthermore, when L‐histidine, a scavenger of singlet oxygen and hydroxyl radical, or D‐mannitol, a scavenger of hydroxyl radical, was used concurrently, the survival rate of tumor cells was significantly higher with L‐histidine. From the above findings, it is surmised that tenoxicam and piroxicam increase the antitumor effects of ultrasound by increasing the production of singlet oxygen and other active oxygen species. Blackwell Publishing Ltd 1999-10 /pmc/articles/PMC5925999/ /pubmed/10595744 http://dx.doi.org/10.1111/j.1349-7006.1999.tb00689.x Text en
spellingShingle Article
Sakusabe, Noboru
Okada, Kyoji
Sato, Kozo
Kamada, Shinko
Yoshida, Yasuo
Suzuki, Toshio
Enhanced Sonodynamic Antitumor Effect of Ultrasound in the Presence of Nonsteroidal Anti‐inflammatory Drugs
title Enhanced Sonodynamic Antitumor Effect of Ultrasound in the Presence of Nonsteroidal Anti‐inflammatory Drugs
title_full Enhanced Sonodynamic Antitumor Effect of Ultrasound in the Presence of Nonsteroidal Anti‐inflammatory Drugs
title_fullStr Enhanced Sonodynamic Antitumor Effect of Ultrasound in the Presence of Nonsteroidal Anti‐inflammatory Drugs
title_full_unstemmed Enhanced Sonodynamic Antitumor Effect of Ultrasound in the Presence of Nonsteroidal Anti‐inflammatory Drugs
title_short Enhanced Sonodynamic Antitumor Effect of Ultrasound in the Presence of Nonsteroidal Anti‐inflammatory Drugs
title_sort enhanced sonodynamic antitumor effect of ultrasound in the presence of nonsteroidal anti‐inflammatory drugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5925999/
https://www.ncbi.nlm.nih.gov/pubmed/10595744
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00689.x
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