Gastric Tumor Induction by 1,2‐Dimethylhydrazine in Wistar Rats with Intestinal Metaplasia Caused by X‐Irradiation

Five‐week‐old male Wistar rats were X‐irradiated with a total of 20 Gy in 2 equal fractions at a 3‐day interval. 1,2‐Dimethylhydrazine (DMH) solution was injected i.m. into the back musculature at a dose of 20 mg/kg body weight weekly for 10 weeks, beginning 20 weeks after the final irradiation. Twe...

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Detalles Bibliográficos
Autores principales: Watanabe, Hiromitsu, Uesaka, Toshihiro, Kido, Shoichirou, Ishimura, Yoshimasa, Shiraki, Kazuhisa, Kuramoto, Ken, Hirata, Shitau, Shoji, Shuneki, Katoh, Osamu, Fujimoto, Nariaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1999
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926017/
https://www.ncbi.nlm.nih.gov/pubmed/10622530
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00697.x
Descripción
Sumario:Five‐week‐old male Wistar rats were X‐irradiated with a total of 20 Gy in 2 equal fractions at a 3‐day interval. 1,2‐Dimethylhydrazine (DMH) solution was injected i.m. into the back musculature at a dose of 20 mg/kg body weight weekly for 10 weeks, beginning 20 weeks after the final irradiation. Twelve months after the initial carcinogen treatment, tumors in the fundus of the glandular stomach were observed in 5 of 23 animals receiving both X‐irradiation and DMH treatment. No tumors of the glandular stomach were observed in the DMH and X‐ray alone or nontreatment groups. It is concluded that the presence of intestinal metaplasia may increase sensitivity to the induction of gastric tumors by carcinogens like DMH.

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