Gastric Tumor Induction by 1,2‐Dimethylhydrazine in Wistar Rats with Intestinal Metaplasia Caused by X‐Irradiation

Five‐week‐old male Wistar rats were X‐irradiated with a total of 20 Gy in 2 equal fractions at a 3‐day interval. 1,2‐Dimethylhydrazine (DMH) solution was injected i.m. into the back musculature at a dose of 20 mg/kg body weight weekly for 10 weeks, beginning 20 weeks after the final irradiation. Twe...

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Autores principales: Watanabe, Hiromitsu, Uesaka, Toshihiro, Kido, Shoichirou, Ishimura, Yoshimasa, Shiraki, Kazuhisa, Kuramoto, Ken, Hirata, Shitau, Shoji, Shuneki, Katoh, Osamu, Fujimoto, Nariaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1999
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926017/
https://www.ncbi.nlm.nih.gov/pubmed/10622530
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00697.x
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author Watanabe, Hiromitsu
Uesaka, Toshihiro
Kido, Shoichirou
Ishimura, Yoshimasa
Shiraki, Kazuhisa
Kuramoto, Ken
Hirata, Shitau
Shoji, Shuneki
Katoh, Osamu
Fujimoto, Nariaki
author_facet Watanabe, Hiromitsu
Uesaka, Toshihiro
Kido, Shoichirou
Ishimura, Yoshimasa
Shiraki, Kazuhisa
Kuramoto, Ken
Hirata, Shitau
Shoji, Shuneki
Katoh, Osamu
Fujimoto, Nariaki
author_sort Watanabe, Hiromitsu
collection PubMed
description Five‐week‐old male Wistar rats were X‐irradiated with a total of 20 Gy in 2 equal fractions at a 3‐day interval. 1,2‐Dimethylhydrazine (DMH) solution was injected i.m. into the back musculature at a dose of 20 mg/kg body weight weekly for 10 weeks, beginning 20 weeks after the final irradiation. Twelve months after the initial carcinogen treatment, tumors in the fundus of the glandular stomach were observed in 5 of 23 animals receiving both X‐irradiation and DMH treatment. No tumors of the glandular stomach were observed in the DMH and X‐ray alone or nontreatment groups. It is concluded that the presence of intestinal metaplasia may increase sensitivity to the induction of gastric tumors by carcinogens like DMH.
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spelling pubmed-59260172018-05-11 Gastric Tumor Induction by 1,2‐Dimethylhydrazine in Wistar Rats with Intestinal Metaplasia Caused by X‐Irradiation Watanabe, Hiromitsu Uesaka, Toshihiro Kido, Shoichirou Ishimura, Yoshimasa Shiraki, Kazuhisa Kuramoto, Ken Hirata, Shitau Shoji, Shuneki Katoh, Osamu Fujimoto, Nariaki Jpn J Cancer Res Article Five‐week‐old male Wistar rats were X‐irradiated with a total of 20 Gy in 2 equal fractions at a 3‐day interval. 1,2‐Dimethylhydrazine (DMH) solution was injected i.m. into the back musculature at a dose of 20 mg/kg body weight weekly for 10 weeks, beginning 20 weeks after the final irradiation. Twelve months after the initial carcinogen treatment, tumors in the fundus of the glandular stomach were observed in 5 of 23 animals receiving both X‐irradiation and DMH treatment. No tumors of the glandular stomach were observed in the DMH and X‐ray alone or nontreatment groups. It is concluded that the presence of intestinal metaplasia may increase sensitivity to the induction of gastric tumors by carcinogens like DMH. Blackwell Publishing Ltd 1999-11 /pmc/articles/PMC5926017/ /pubmed/10622530 http://dx.doi.org/10.1111/j.1349-7006.1999.tb00697.x Text en
spellingShingle Article
Watanabe, Hiromitsu
Uesaka, Toshihiro
Kido, Shoichirou
Ishimura, Yoshimasa
Shiraki, Kazuhisa
Kuramoto, Ken
Hirata, Shitau
Shoji, Shuneki
Katoh, Osamu
Fujimoto, Nariaki
Gastric Tumor Induction by 1,2‐Dimethylhydrazine in Wistar Rats with Intestinal Metaplasia Caused by X‐Irradiation
title Gastric Tumor Induction by 1,2‐Dimethylhydrazine in Wistar Rats with Intestinal Metaplasia Caused by X‐Irradiation
title_full Gastric Tumor Induction by 1,2‐Dimethylhydrazine in Wistar Rats with Intestinal Metaplasia Caused by X‐Irradiation
title_fullStr Gastric Tumor Induction by 1,2‐Dimethylhydrazine in Wistar Rats with Intestinal Metaplasia Caused by X‐Irradiation
title_full_unstemmed Gastric Tumor Induction by 1,2‐Dimethylhydrazine in Wistar Rats with Intestinal Metaplasia Caused by X‐Irradiation
title_short Gastric Tumor Induction by 1,2‐Dimethylhydrazine in Wistar Rats with Intestinal Metaplasia Caused by X‐Irradiation
title_sort gastric tumor induction by 1,2‐dimethylhydrazine in wistar rats with intestinal metaplasia caused by x‐irradiation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926017/
https://www.ncbi.nlm.nih.gov/pubmed/10622530
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00697.x
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