Somatic Mutations in RET Exons 12 and 15 in Sporadic Medullary Thyroid Carcinomas: Different Spectrum of Mutations in Sporadic Type from Hereditary Type

Germline mutations in the RET proto‐oncogene are responsible for multiple endocrine neoplasia type 2 (MEN 2A and 2B) and familial medullary thyroid carcinoma (FMTC). Point mutations or in‐frame deletions of exons 10, 11, 13, 14 and 16 are associated with sporadic medullary thyroid carcinoma (MTC). T...

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Detalles Bibliográficos
Autores principales: Uchino, Shinya, Noguchi, Shiro, Yamashita, Hiroto, Sato, Mari, Adachi, Mitsuo, Yamashita, Hiroyuki, Watanabe, Shin, Ohshima, Akira, Mitsuyama, Shoshu, Iwashita, Toshihide, Takahashi, Masahide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1999
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926019/
https://www.ncbi.nlm.nih.gov/pubmed/10622534
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00701.x

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