Cargando…

Expression of Thymidylate Synthase in Human Non‐small Cell Lung Cancer

5‐Fluorouracil (5‐FU) has been used worldwide, and the correlation between its effects and thymidylate synthase (TS) expression has been reported in gastrointestinal malignancy. But the significance of TS expression for 5‐FU‐based chemotherapy has rarely been reported in non‐small cell lung cancer (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Otake, Yosuke, Tanaka, Fumihiro, Yanagihara, Kazuhiro, Hitomi, Shigeki, Okabe, Hiroyuki, Fukushima, Masakazu, Wada, Hiromi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 1999
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926020/ https://www.ncbi.nlm.nih.gov/pubmed/10622537 http://dx.doi.org/10.1111/j.1349-7006.1999.tb00704.x

Ejemplares similares

p53 Status Predicts the Efficacy of Postoperative Oral Administration of Tegafur for Completely Resected Non‐small Cell Lung Cancer
por: Tanaka, Fumihiro, et al.
Publicado: (1999)

Interstitial lung disease in gefitinib-treated Japanese patients with non-small cell lung cancer – a retrospective analysis: JMTO LC03-02
por: Nakagawa, Masatsugu, et al.
Publicado: (2009)

Effect of Hammerhead Ribozyme against Human Thymidylate Synthase on the Cytotoxicity of Thymidylate Synthase Inhibitors
por: Kobayashi, Hiroyuki, et al.
Publicado: (1995)

Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer
por: Takezawa, K, et al.
Publicado: (2011)

Prognostic significance of thymidylate synthase in postoperative non-small cell lung cancer patients
por: Zhao, Hong-Yun, et al.
Publicado: (2014)

The pemetrexed-containing treatments in the non-small cell lung cancer, is -/low thymidylate synthase expression better than +/high thymidylate synthase expression: a meta-analysis
por: Wang, Lei, et al.
Publicado: (2014)

Rapamycin downregulates thymidylate synthase and potentiates the activity of pemetrexed in non-small cell lung cancer
por: Kawabata, Shigeru, et al.
Publicado: (2014)

Thymidylate synthase drives the phenotypes of epithelial-to-mesenchymal transition in non-small cell lung cancer
por: Siddiqui, Mohammad Aarif, et al.
Publicado: (2020)

A novel intraperitoneal therapy for gastric cancer with DFP‐10825, a unique RNAi therapeutic targeting thymidylate synthase, in a peritoneally disseminated xenograft model
por: Ando, Hidenori, et al.
Publicado: (2019)

Perimembrane Aurora-A Expression is a Significant Prognostic Factor in Correlation with Proliferative Activity in Non-Small-Cell Lung Cancer (NSCLC)
por: Ogawa, Eiji, et al.
Publicado: (2007)

Early detection of thymidylate synthase resistance in non-small cell lung cancer with FLT-PET imaging
por: Chen, Xiao, et al.
Publicado: (2017)

Trichinella pseudospiralis vs. T. spiralis thymidylate synthase gene structure and T. pseudospiralis thymidylate synthase retrogene sequence
por: Jagielska, Elżbieta, et al.
Publicado: (2014)

Correlation between thymidylate synthase gene polymorphisms and efficacy of pemetrexed in advanced non-small cell lung cancer
por: HU, QIONG, et al.
Publicado: (2012)

Thymidylate synthase expression as a predictive biomarker of pemetrexed sensitivity in advanced non-small cell lung cancer
por: Chamizo, Cristina, et al.
Publicado: (2015)

Dynamic Modulation of Thymidylate Synthase Gene Expression and Fluorouracil Sensitivity in Human Colorectal Cancer Cells
por: Wakasa, Kentaro, et al.
Publicado: (2015)

Conservation and Role of Electrostatics in Thymidylate Synthase
por: Garg, Divita, et al.
Publicado: (2015)

Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging
por: Chen, Xiao, et al.
Publicado: (2016)

The deubiquitinating enzyme UCHL1 promotes resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase
por: Ding, Xinyuan, et al.
Publicado: (2020)

Identification of thymidylate synthase as a potential therapeutic target for lung cancer
por: Takezawa, K, et al.
Publicado: (2010)

Predictive value of thymidylate synthase for the prognosis and survival of lung adenocarcinoma patients
por: HUANG, YAN, et al.
Publicado: (2015)

Substrate Activation in Flavin-Dependent Thymidylate Synthase
por: Mishanina, Tatiana V., et al.
Publicado: (2014)

Concerted versus Stepwise Mechanism in Thymidylate Synthase
por: Islam, Zahidul, et al.
Publicado: (2014)

Astrocyte-elevated gene-1 confers resistance to pemetrexed in non-small cell lung cancer by upregulating thymidylate synthase expression
por: Chen, Chung-Yu, et al.
Publicado: (2017)

Dexamethasone pretreatment impairs the thymidylate synthase inhibition mediated flare in thymidine salvage pathway activity in non-small cell lung cancer
por: Chen, Xiao, et al.
Publicado: (2018)

Quantitative Measurement of Thymidylate Synthase and Dihydropyrimidine Dehydrogenase mRNA Level in Gastric Cancer by Real‐time RT‐PCR
por: Fujiwara, Hisataka, et al.
Publicado: (2002)

Expression of thymidylate synthase and orotate phosphoribosyltransferase in thymic carcinoma
por: YOKOTA, KEISUKE, et al.
Publicado: (2012)

Analysis of mRNA recognition by human thymidylate synthase
por: Brunn, Nicholas D., et al.
Publicado: (2014)

Bacterial versus human thymidylate synthase: Kinetics and functionality
por: Islam, Zahidul, et al.
Publicado: (2018)

Dynamic allostery in substrate binding by human thymidylate synthase
por: Bonin, Jeffrey P, et al.
Publicado: (2022)

Effect of small interfering RNA 3'-end overhangs on chemosensitivity to thymidylate synthase inhibitors
por: Schmitz, John C, et al.
Publicado: (2011)

Apoptosis and p53 status predict the efficacy of postoperative administration of UFT in non-small cell lung cancer
por: Tanaka, F, et al.
Publicado: (2001)

Predictive and Prognostic Value of (18)F-fluorodeoxyglucose Uptake Combined with Thymidylate Synthase Expression in Patients with Advanced Non-Small Cell Lung Cancer
por: Moon, Seung Hwan, et al.
Publicado: (2019)

Anticancer activity of the intraperitoneal-delivered DFP-10825, the cationic liposome-conjugated RNAi molecule targeting thymidylate synthase, on peritoneal disseminated ovarian cancer xenograft model
por: Iizuka, Kenzo, et al.
Publicado: (2018)

An Evolutionary Analysis of Lateral Gene Transfer in Thymidylate Synthase Enzymes
por: Stern, Adi, et al.
Publicado: (2010)

Translational repression of thymidylate synthase by targeting its mRNA
por: Garg, Divita, et al.
Publicado: (2013)

Significance of thymidylate synthase expression for resistance to pemetrexed in pulmonary adenocarcinoma
por: YANG, MIN, et al.
Publicado: (2014)

Mechanistic and structural basis for inhibition of thymidylate synthase ThyX
por: Basta, Tamara, et al.
Publicado: (2012)

Thymidylate Synthase as a Predictive Biomarker for Pemetrexed Response in NSCLC
por: Bukhari, Ali A., et al.
Publicado: (2013)

Flavin-Dependent Thymidylate Synthase as a New Antibiotic Target
por: Choi, Michael, et al.
Publicado: (2016)

Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities
por: Maj, Piotr, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1pv37c2fngi8ekqjdp28am9n0c