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Significance of Membrane Type 1 Matrix Metalloproteinase Expression in Breast Cancer

Expression of matrix metalloproteinases (MMPs) plays an essential role in tumor metastasis and invasion through the degradation of extracellular matrix (ECM). MT1‐MMP (membrane type 1 matrix metalloproteinase), a membrane‐type MMP, is responsible for the activation of MMP2. In this study the signifi...

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Autores principales: Ishigaki, Shinsuke, Toi, Masakazu, Ueno, Takayuki, Matsumoto, Hiroshi, Muta, Mariko, Koike, Morio, Seiki, Motoharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 1999
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926108/
https://www.ncbi.nlm.nih.gov/pubmed/10391091
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00778.x
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author Ishigaki, Shinsuke
Toi, Masakazu
Ueno, Takayuki
Matsumoto, Hiroshi
Muta, Mariko
Koike, Morio
Seiki, Motoharu
author_facet Ishigaki, Shinsuke
Toi, Masakazu
Ueno, Takayuki
Matsumoto, Hiroshi
Muta, Mariko
Koike, Morio
Seiki, Motoharu
author_sort Ishigaki, Shinsuke
collection PubMed
description Expression of matrix metalloproteinases (MMPs) plays an essential role in tumor metastasis and invasion through the degradation of extracellular matrix (ECM). MT1‐MMP (membrane type 1 matrix metalloproteinase), a membrane‐type MMP, is responsible for the activation of MMP2. In this study the significance of MT1‐MMP expression in human breast tumors was investigated by immunocytochemical assay, and its correlation with clinicobiological features was analyzed. MT1‐MMP expression was detected in tumor cells and/or stromal cells, and there was a strong correlation between the expressions of MT1‐MMP in the two cell types. Out of 183 primary tumors, 103 (56.2%) showed positive staining of MT1‐MMP in tumor cells. MT1‐MMP expression showed no significant correlation with any of the clinicobiological parameters examined, including hormone receptor status and angiogenesis. In postoperative survival analysis, MT1‐MMP expression itself was not a significant prognostic factor. However, in the particular subgroup with the accumulation of thymidine phosphorylase (TP)‐positive stromal cells, which have been activated by various stimuli, such as cytokines and hypoxia, MT1‐MMP expression had a significant prognostic value. These data suggested that MT1‐MMP might function cooperatively with tumor‐associated stromal cells for the progression of breast cancer.
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spelling pubmed-59261082018-05-11 Significance of Membrane Type 1 Matrix Metalloproteinase Expression in Breast Cancer Ishigaki, Shinsuke Toi, Masakazu Ueno, Takayuki Matsumoto, Hiroshi Muta, Mariko Koike, Morio Seiki, Motoharu Jpn J Cancer Res Article Expression of matrix metalloproteinases (MMPs) plays an essential role in tumor metastasis and invasion through the degradation of extracellular matrix (ECM). MT1‐MMP (membrane type 1 matrix metalloproteinase), a membrane‐type MMP, is responsible for the activation of MMP2. In this study the significance of MT1‐MMP expression in human breast tumors was investigated by immunocytochemical assay, and its correlation with clinicobiological features was analyzed. MT1‐MMP expression was detected in tumor cells and/or stromal cells, and there was a strong correlation between the expressions of MT1‐MMP in the two cell types. Out of 183 primary tumors, 103 (56.2%) showed positive staining of MT1‐MMP in tumor cells. MT1‐MMP expression showed no significant correlation with any of the clinicobiological parameters examined, including hormone receptor status and angiogenesis. In postoperative survival analysis, MT1‐MMP expression itself was not a significant prognostic factor. However, in the particular subgroup with the accumulation of thymidine phosphorylase (TP)‐positive stromal cells, which have been activated by various stimuli, such as cytokines and hypoxia, MT1‐MMP expression had a significant prognostic value. These data suggested that MT1‐MMP might function cooperatively with tumor‐associated stromal cells for the progression of breast cancer. Blackwell Publishing Ltd 1999-05 /pmc/articles/PMC5926108/ /pubmed/10391091 http://dx.doi.org/10.1111/j.1349-7006.1999.tb00778.x Text en
spellingShingle Article
Ishigaki, Shinsuke
Toi, Masakazu
Ueno, Takayuki
Matsumoto, Hiroshi
Muta, Mariko
Koike, Morio
Seiki, Motoharu
Significance of Membrane Type 1 Matrix Metalloproteinase Expression in Breast Cancer
title Significance of Membrane Type 1 Matrix Metalloproteinase Expression in Breast Cancer
title_full Significance of Membrane Type 1 Matrix Metalloproteinase Expression in Breast Cancer
title_fullStr Significance of Membrane Type 1 Matrix Metalloproteinase Expression in Breast Cancer
title_full_unstemmed Significance of Membrane Type 1 Matrix Metalloproteinase Expression in Breast Cancer
title_short Significance of Membrane Type 1 Matrix Metalloproteinase Expression in Breast Cancer
title_sort significance of membrane type 1 matrix metalloproteinase expression in breast cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5926108/
https://www.ncbi.nlm.nih.gov/pubmed/10391091
http://dx.doi.org/10.1111/j.1349-7006.1999.tb00778.x
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